Universität zu Köln

Berthold, Heiner K., Laudes, Matthias, Krone, Wilhelm and Gouni-Berthold, Ioanna (2011). Association between the Interleukin-6 Promoter Polymorphism-174G/C and Serum Lipoprotein(a) Concentrations in Humans. PLoS One, 6 (9). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background: Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease. The interleukin-6 (IL-6) receptor antagonist tocilizumab has been shown to lower serum Lp(a) concentrations. We investigated whether the IL-6 single nucleotide polymorphism -174G/C is associated with baseline serum Lp(a) concentrations. Methodology/Principal Findings: We divided 2321 subjects from the Lipid Analytic Cologne (LIANCO) cohort into 2 groups, the ones with substantially elevated Lp(a), defined as concentrations >= 60 mg/dl (n = 510), and the ones with Lp(a) <60 mg/dl (n = 1811). The association with the genotypes GG (33.7%), GC (50.75%) and CC (15.55%) was investigated. The GC and the CC genotype were associated with a significantly increased odds ratio of having substantially elevated Lp(a) concentrations (OR = 1.3, 95% CI 1.04 to 1.63, P = 0.02 and OR = 1.44, 95% CI 1.06 to 1.93, P = 0.018). These associations remained significant after adjusting for age, sex, smoking behavior, body mass index, serum lipoproteins, hypertension and diabetes. Of these covariates, only LDL cholesterol was significantly and independently associated with elevated Lp(a) concentrations. Conclusions/Significance: The IL-6 single nucleotide polymorphism -174G/C is associated with increased odds of having elevated Lp(a). Whether this association plays a role in the Lp(a)-lowering effects of IL-6 receptor antagonists remains to be established.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Berthold, Heiner K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laudes, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Krone, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489046
DOI:	10.1371/journal.pone.0024719
Journal or Publication Title:	PLoS One
Volume:	6
Number:	9
Date:	2011
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; PLASMA IL-6 LEVELS; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; GENE POLYMORPHISM; APOLIPOPROTEIN-B; CONTROLLED TRIAL; FOLLOW-UP; RISK Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48904