Universität zu Köln

Wojtecki, Lars, Elben, Saskia, Timmermann, Lars, Reck, Christiane, Maarouf, Mohammad, Joergens, Silke, Ploner, Markus ORCID: 0000-0002-7767-7170, Suedmeyer, Martin, Groiss, Stefan Jun, Sturm, Volker, Niedeggen, Michael and Schnitzler, Alfons ORCID: 0000-0002-6414-7939 (2011). Modulation of Human Time Processing by Subthalamic Deep Brain Stimulation. PLoS One, 6 (9). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Timing in the range of seconds referred to as interval timing is crucial for cognitive operations and conscious time processing. According to recent models of interval timing basal ganglia (BG) oscillatory loops are involved in time interval recognition. Parkinsons disease (PD) is a typical disease of the basal ganglia that shows distortions in interval timing. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a powerful treatment of PD which modulates motor and cognitive functions depending on stimulation frequency by affecting subcortical-cortical oscillatory loops. Thus, for the understanding of BG-involvement in interval timing it is of interest whether STN-DBS can modulate timing in a frequency dependent manner by interference with oscillatory time recognition processes. We examined production and reproduction of 5 and 15 second intervals and millisecond timing in a double blind, randomised, within-subject repeated-measures design of 12 PD-patients applying no, 10-Hz- and >= 130-Hz-STN-DBS compared to healthy controls. We found under(re) production of the 15-second interval and a significant enhancement of this under(re-)production by 10-Hz-stimulation compared to no stimulation, >= 130-Hz-STN-DBS and controls. Milliseconds timing was not affected. We provide first evidence for a frequency-specific modulatory effect of STN-DBS on interval timing. Our results corroborate the involvement of BG in general and of the STN in particular in the cognitive representation of time intervals in the range of multiple seconds.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wojtecki, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Elben, Saskia UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Reck, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Joergens, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Ploner, Markus UNSPECIFIED orcid.org/0000-0002-7767-7170 UNSPECIFIED Suedmeyer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Groiss, Stefan Jun UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Niedeggen, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnitzler, Alfons UNSPECIFIED orcid.org/0000-0002-6414-7939 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489102
DOI:	10.1371/journal.pone.0024589
Journal or Publication Title:	PLoS One
Volume:	6
Number:	9
Date:	2011
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEUS STIMULATION; BASAL GANGLIA; PARKINSONS-DISEASE; NEURAL REPRESENTATION; PERCEPTION; PALLIDUM; REPRODUCTION; OSCILLATIONS; ACTIVATION; MECHANISMS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48910