Universität zu Köln

Grefkes, C. (2011). Network Disorders after Stroke: New Aspects from Functional Magnetic Resonance Imaging. Klin. Neurophysiol., 42 (3). S. 177 - 183. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4081

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Abstract

The sensorimotor system comprises a network of cortical and subcortical areas which interact by means of excitatory or inhibitory circuits finally leading to motor output. The balance within this network may be critically disturbed following stroke if the lesion either directly affects any of these areas or damages white matter fibres connecting critical regions. Such effects can be detected by means of functional neuroimaging techniques like positron emission tomography (PET) or functional magnetic resonance imaging (fMRI) and analyses of connectivity. Estimating effective connectivity by means of dynamic causal modelling (DCM) reveals that, after stroke, changes in both intra- and interhemispheric interactions among cortical regions constitute an important pathophysiological aspect of motor impairment in stroke patients. Such disturbances can be partially corrected by non-invasive brain stimulation approaches. Likewise, stimulating noradrenergic mechanisms may also induce a rearrangement of the functional network architecture of the sensorimotor system, which might be useful in a rehabilitative setting with stroke patients. In summary, analyses of effective connectivity may further our understanding of the pathophysiology underlying motor symptoms after stroke, and may help to design hypothesis-driven treatment strategies to support recovery of motor function in patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grefkes, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489670
DOI:	10.1055/s-0031-1285855
Journal or Publication Title:	Klin. Neurophysiol.
Volume:	42
Number:	3
Page Range:	S. 177 - 183
Date:	2011
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-4081
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY MOTOR CORTEX; CEREBRAL-BLOOD-FLOW; DEPENDENT PLASTICITY; MOVEMENT KINEMATICS; BRAIN-STIMULATION; CORTICAL NETWORKS; HEALTHY-SUBJECTS; PREMOTOR CORTEX; RECOVERY; REORGANIZATION Multiple languages Clinical Neurology; Neuroimaging; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48967