Yu, Liangzhu, Gao, Shijun, Nie, Li, Tang, Ming, Huang, Weifeng, Luo, Hongyan, Hu, Xinwu, Xi, Jiaoya, Zhu, Minjie, Zheng, Yunjie, Gao, Linlin, Zhang, Lanqiu, Song, Yuanlong, Hescheler, Juergen and Liang, Huamin (2011). Molecular and Functional Changes in Voltage-Gated Na+ Channels in Cardiomyocytes During Mouse Embryogenesis. Circ. J., 75 (9). S. 2071 - 2080. TOYKO: JAPANESE CIRCULATION SOC. ISSN 1347-4820
Full text not available from this repository.Abstract
Background: Embryonic cardiomyocytes undergo profound changes in their electrophysiological properties during development. However, the molecular and functional changes in Na+ channel during cardiogenesis are not yet fully explained. Methods and Results: To study the functional changes in the Na+ channel during cardiogenesis, Na+ currents were recorded in the early (EDS) and late (LDS) developmental stages of cardiomyocytes in embryonic mice. Compared with EDS myocytes, LDS myocytes exhibited a larger peak current density, a more negative shift in the voltage of half inactivation, a larger fast inactivation component and a smaller slow inactivation component, and smaller time constants for recovery from inactivation. Additionally, multiple Na+ channel alpha-subunits (Nay 1.1-1.6) and beta-subunits (Nay beta 1-beta 3) of mouse embryos were investigated. Transcripts of Nay 1.1-1.3 were absent or present at very low levels in embryonic hearts. Transcripts encoding Nay 1.4-1.6 and Nay beta 1-beta 3 increased during embryogenesis. Data on the sensitivity of total Na+ currents to tetrodotoxin (TTX) showed that TTX-resistant Nay 1.5 is the predominant isoform expressed in the heart of the mouse embryo. Conclusions: The results indicate that significant changes in the functional properties of Na+ channels develop in the cardiomyocytes of the mouse embryo, and that different Na+ channel subunit genes are strongly regulated during embryogenesis, which further support a physiological role for voltage-gated Na+ channels during heart development. (Circ J 2011; 75: 2071-2079)
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| URN: | urn:nbn:de:hbz:38-489927 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1253/circj.CJ-10-1212 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Circ. J. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Volume: | 75 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number: | 9 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Page Range: | S. 2071 - 2080 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Date: | 2011 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | JAPANESE CIRCULATION SOC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Place of Publication: | TOYKO | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1347-4820 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/48992 |
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