Universität zu Köln

Deneke, Thomas, Chaar, Huda, de Groot, Joris R., Wilde, Arthur A., Lawo, Thomas, Mundig, Johanna, Boesche, Leif, Muegge, Andreas and Grewe, Peter H. (2011). Shift in the pattern of autonomic atrial innervation in subjects with persistent atrial fibrillation. Heart Rhythm, 8 (9). S. 1357 - 1364. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1547-5271

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Abstract

BACKGROUND Atrial fibrillation (AF) is a multifactorial disease of the atria. OBJECTIVE We studied the differences in the atrial autonomic innervation pattern in subjects with AF compared with sinus rhythm (SR). METHODS Preparation of postmortem isolated hearts of subjects with documented persistent AF (group A) and SR (group B) included: (1) histological sectioning of predefined areas and quantification of nerve density, and (2) differentiation using immunohistochemistry in adrenergic (sympathetic, tyrosine-hydroxylase antibody), cholinergic (parasympathetic, choline-acetyltransferase antibody) and mixed (adrenergic and cholinergic staining) nerves. RESULTS Characteristics of subjects in group A (N = 15) and group B (N = 24) did not differ. The mean overall nerve density was similar between groups (A: 0.31 +/- 0.25/mm(2); B: 0.35 +/- 0.25/mm(2); P = .87). Nerve density appeared higher in the region of the pulmonary vein ostia and antrum (group A: 0.38 +/- 0.21/mm(2); group B: 0.32 +/- 0.19/mm(2),) compared with other locations of the right and left atrium. A total of 2,224 (group A: 685; group B: 1539) nerves were differentiated using immunohistochemistry. There was a high degree of colocalization of adrenergic and cholinergic nerves (group A: 80% mixed staining, group B: 69% mixed staining). In group A hearts there was a significantly lower density of predominantly cholinergic nerves (0.025 +/- 0.052/mm(2) vs. 0.058 +/- 0.099/mm(2); P = .008) and a higher density of nerves containing adrenergic components (0.24 +/- 0.18/mm(2) vs. 0.18 +/- 0.17/mm(2), P = .046). CONCLUSION Overall autonomic nerve density did not differ between atria with persistent AF compared with SR. On a morphological level, we detected a shift toward a lower density of cholinergic nerves and a higher density of nerves containing adrenergic components in AF subjects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Deneke, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaar, Huda UNSPECIFIED UNSPECIFIED UNSPECIFIED de Groot, Joris R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilde, Arthur A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawo, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Mundig, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Boesche, Leif UNSPECIFIED UNSPECIFIED UNSPECIFIED Muegge, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Grewe, Peter H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490053
DOI:	10.1016/j.hrthm.2011.04.013
Journal or Publication Title:	Heart Rhythm
Volume:	8
Number:	9
Page Range:	S. 1357 - 1364
Date:	2011
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1547-5271
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYMPATHETIC HYPERINNERVATION; RADIOFREQUENCY ABLATION; STIMULATION; ARRHYTHMIAS; HEARTS; NERVES; DOGS Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49005