Universität zu Köln

Moesges, Ralph, Graute, Vera, Christ, Hildegard ORCID: 0000-0003-3235-2994, Sieber, Hans-Jochen, Wahn, Ulrich and Niggemann, Bodo (2010). Safety of ultra-rush titration of sublingual immunotherapy in asthmatic children with tree-pollen allergy. Pediatr. Allergy Immunol., 21 (8). S. 1135 - 1139. HOBOKEN: WILEY. ISSN 1399-3038

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Abstract

The recommendation to use sublingual-swallow immunotherapy (SLIT) in children and adults with allergic rhinitis has been established over the past decade. Recently, ultra-rush titration of SLIT has become more and more common, raising concerns about its safety in children with asthma. Fifty-four children with asthma and adolescents aged 6-14 with documented allergic disease because of tree pollen (birch and possibly alder and/or hazel) from 14 study centers in Germany participated in a randomized, double-blind, and placebo-controlled study. Twenty-seven were randomized to receive SLIT with standardized birch pollen allergen extract and the other 27 to receive placebo. An ultra-rush high-dose SLIT titration regimen reaching the maintenance dose of 300 index of reactivity (IR) within 90 min (30-90-150-300 IR) was used. The difference in mean PFR changes during ultra-rush titration between SLIT and placebo was not significant (p = 0.056). A 95% probability that SLIT does not decrease PFR during ultra-rush titration was demonstrated. Neither anaphylactic shock nor else serious systemic reactions to the study drug occurred. No serious adverse event assessed by the investigator as related to study drug treatment was reported.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED Graute, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Christ, Hildegard UNSPECIFIED orcid.org/0000-0003-3235-2994 UNSPECIFIED Sieber, Hans-Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahn, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Niggemann, Bodo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-491970
DOI:	10.1111/j.1399-3038.2010.01078.x
Journal or Publication Title:	Pediatr. Allergy Immunol.
Volume:	21
Number:	8
Page Range:	S. 1135 - 1139
Date:	2010
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-3038
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SWALLOW IMMUNOTHERAPY; DOUBLE-BLIND; RHINITIS; TOLERABILITY; EFFICACY Multiple languages Allergy; Immunology; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49197