Universität zu Köln

Neumann, Sascha, Schneider, Maria, Daugherty, Rebecca L., Gottardi, Cara J., Eming, Sabine A., Beijer, Asa, Noegel, Angelika A. and Karakesisoglou, Iakowos (2010). Nesprin-2 Interacts with alpha-Catenin and Regulates Wnt Signaling at the Nuclear Envelope. J. Biol. Chem., 285 (45). S. 34932 - 34939. BETHESDA: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC. ISSN 0021-9258

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Abstract

Nesprins and emerin are structural nuclear envelope proteins that tether nuclei to the cytoskeleton. In this work, we identified the cytoskeleton-associated alpha-N/E-catenins as novel nesprin-2-binding partners. The association involves the C termini of nesprin-2 giant and alpha-N/E-catenins. alpha-E/T/N-catenins are known primarily for their roles in cadherin-mediated cell-cell adhesion. Here, we show that, in addition, alpha-catenin forms complexes with nesprin-2 that include beta-catenin and emerin. We demonstrate that the depletion of nesprin-2 reduces both the amount of active beta-catenin inside the nucleus and T-cell factor/lymphoid-enhancing factor-dependent transcription. Taken together, these findings suggest novel nesprin-2 functions in cellular signaling. Moreover, we propose that, in contrast to emerin, nesprin-2 is a positive regulator of the Wnt signaling pathway.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neumann, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Daugherty, Rebecca L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottardi, Cara J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beijer, Asa UNSPECIFIED UNSPECIFIED UNSPECIFIED Noegel, Angelika A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karakesisoglou, Iakowos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-492660
DOI:	10.1074/jbc.M110.119651
Journal or Publication Title:	J. Biol. Chem.
Volume:	285
Number:	45
Page Range:	S. 34932 - 34939
Date:	2010
Publisher:	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Place of Publication:	BETHESDA
ISSN:	0021-9258
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BETA-CATENIN; MEMBRANE PROTEIN; N-CATENIN; EMERIN; CELLS; LOCALIZATION; ACTIVATION; ANCHORAGE; ISOFORMS; DOMAINS Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49266