Universität zu Köln

Javeri, Sita, Rodi, Michael, Tary-Lehmann, Magdalena, Lehmann, Paul V., Addicks, Klaus and Kuerten, Stefanie (2010). Involvement of brain-derived neurotrophic factor (BDNF) in MP4-induced autoimmune encephalomyelitis. Clin. Immunol., 137 (2). S. 181 - 190. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1521-7035

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Abstract

The role of brain-derived neurotrophic factor (BDNF) in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still unclear. Here we investigate the clinical course, CNS histopathology and peripheral antigen-specific immunity in MP4-induced EAE of BDNF (-/+) mice. We demonstrate that these mice displayed less severe disease compared to BDNF (+/+) mice, reflected by decreased inflammation and demyelination. In correspondence to diminished frequencies of T and B cells in CNS infiltrates, the peripheral MP4-specific T(H)1/T(H)17 response was attenuated in BDNF (-/+), but not in wild-type animals. In contrast, immunization with ovalbumin triggered similar frequencies of IFN-gamma- and IL-17-secreting T cells in both groups. The cytokine secretion and proliferative activity upon mitogen stimulation did not reveal any global defect of T cell function in BDNF (-/+) mice. By influencing the antigen-specific immune response in autoimmune encephalomyelitis, BDNF may support and maintain the disease in ways that go beyond its alleged neuroprotective role. (C) 2010 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Javeri, Sita UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodi, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Tary-Lehmann, Magdalena UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Paul V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Addicks, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuerten, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493079
DOI:	10.1016/j.clim.2010.08.001
Journal or Publication Title:	Clin. Immunol.
Volume:	137
Number:	2
Page Range:	S. 181 - 190
Date:	2010
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1521-7035
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language C57BL/6 MICE; MULTIPLE-SCLEROSIS; MESSENGER-RNA; SPINAL-CORD; CELLS; EAE; PROTEIN Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49307