Universität zu Köln

Heiligenhaus, Arnd, Thurau, Stephan, Hennig, Maren, Grajewski, Rafael S. and Wildner, Gerhild (2010). Anti-inflammatory treatment of uveitis with biologicals: new treatment options that reflect pathogenetic knowledge of the disease. Graefes Arch. Clin. Exp. Ophthalmol., 248 (11). S. 1531 - 1552. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

Endogenous uveitis is a sight-threatening disease. In addition to corticosteroids, immunosuppressive agents are commonly used to treat patients with severe course. Immunosuppressive drugs act nonspecifically, rather than providing a specific interaction with the critical pathogenetic pathways of uveitis. Better knowledge of the basic mechanisms underlying uveitis and of the molecules that are important for regulating inflammation has helped to create new and more specific treatment approaches. Biological therapy for inflammatory diseases employs substances that interfere with specific molecules or pathways induced in the body during the inflammatory process. This review gives an overview on molecules that play a critical role in the pathogenetic process of uveitis, as has been observed in patients or the respective animal models, and summarizes the current experience with biologicals for the treatment of uveitis refractive to conventional immunosuppressives.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heiligenhaus, Arnd UNSPECIFIED UNSPECIFIED UNSPECIFIED Thurau, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennig, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Grajewski, Rafael S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wildner, Gerhild UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493344
DOI:	10.1007/s00417-010-1485-8
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	248
Number:	11
Page Range:	S. 1531 - 1552
Date:	2010
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTOXIN-INDUCED UVEITIS; JUVENILE IDIOPATHIC ARTHRITIS; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TUMOR-NECROSIS-FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; SYSTEMIC-LUPUS-ERYTHEMATOSUS; REGULATORY T-CELLS; OCULAR INFLAMMATORY DISEASE; ANTIBODY-ASSOCIATED VASCULITIS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49334