Universität zu Köln

Hacker, U., Hallek, M. and Kubicka, S. (2010). Multimodality therapy of colorectal cancer. Internist, 51 (11). S. 1366 - 1372. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1289

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Abstract

Adjuvant chemotherapy for resected stage Ill colon cancer is indicated for all patients, including elderly patients >70 years. In general, adjuvant oxaliplatin-fluoropyrimidine chemotherapy should be started within 6 weeks after tumor resection and should be given for a period of 6 months. However, patients aged >70 should receive fluoropyrimidine mono-chemotherapy. This mono-therapy, but not an oxaliplatin-based combination, can also be considered for patients with standard risk stage II tumors without microsatellite instability. In stage II patients with a high risk constellation adjuvant oxaliplatin-fluoropyrimidine combination therapy should be considered. Patients with stage II and III rectal cancer require neoadjuvant radiochemotherapy with fluoropyrimidine followed by adjuvant fluoropyrimidine treatment. There is no role for the use of VEGF- or EGFR-antibodies in the adjuvant therapy of colon cancer or in neoadjuvant therapy of rectal cancer. The prognosis of patients with primary resectable colorectal liver metastases may be improved by adjuvant or perioperative chemotherapy, while neoadjuvant systemic chemotherapy frequently facilitates potential curative resection of initially non-resectable liver metastases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hacker, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kubicka, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493442
DOI:	10.1007/s00108-010-2671-9
Journal or Publication Title:	Internist
Volume:	51
Number:	11
Page Range:	S. 1366 - 1372
Date:	2010
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1289
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TOTAL MESORECTAL EXCISION; III COLON-CANCER; PREOPERATIVE RADIOTHERAPY; ADJUVANT TREATMENT; STAGE-II; LIVER METASTASES; RECTAL-CANCER; CHEMOTHERAPY; FLUOROURACIL; OXALIPLATIN Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49344