Universität zu Köln

Wendtner, C. -M., Delank, S. and Eich, H. (2010). Multimodality therapy concepts for soft tissue sarcomas. Internist, 51 (11). S. 1388 - 1396. NEW YORK: SPRINGER. ISSN 0020-9554

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Abstract

Despite the fact that soft tissue sarcomas are representing a rare tumor entity with a low incidence rate of about 2-4 per 100.000 per year, they highly require a multimodality therapeutic approach. Based on a reference pathology a complete surgical resection is the first treatment goal. After accomplished R0 resection the local relapse rate can be further decreased by an adjuvant radiotherapy. For primarily irresectable or only partially respectable tumors a neoadjuvant chemotherapy combined with regional hyperthermia should be considered. Patients with metastasized soft tissue sarcomas should receive an anthracyclin-based chemotherapy in a palliative intention. Prognostically more favorable are gastrointestinal stroma tumor, also in advanced stages with metastases, since the tyrosine kinase inhibitors imatinib and sunitinib can induce durable remissions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wendtner, C. -M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Delank, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eich, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493458
DOI:	10.1007/s00108-010-2672-8
Journal or Publication Title:	Internist
Volume:	51
Number:	11
Page Range:	S. 1388 - 1396
Date:	2010
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	0020-9554
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GASTROINTESTINAL STROMAL TUMORS; NEOADJUVANT CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; REGIONAL HYPERTHERMIA; SINGLE INSTITUTION; RADIATION-THERAPY; RANDOMIZED-TRIAL; SPARING SURGERY; IMATINIB; EXTREMITIES Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49345