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Pfister, Roman, Strack, Nicole, Wielckens, Klaus, Malchau, Gebhart, Erdmann, Erland and Schneider, Christian A. (2010). The relationship and prognostic impact of low-T3 syndrome and NT-pro-BNP in cardiovascular patients. Int. J. Cardiol., 144 (2). S. 187 - 191. CLARE: ELSEVIER IRELAND LTD. ISSN 0167-5273

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Abstract

Objectives: Low-T3 syndrome is highly prevalent and independently prognostic in cardiovascular patients. The relationship and prognostic impact with the cardiac marker NT-pro-BNP have not been thoroughly investigated. Methods: Thyroid hormone levels and NT-pro-BNP were assessed in 615 consecutive patients hospitalized for cardiovascular disease. Patients with primary overt or latent thyroid disorder, hormone replacement, thyreostatic and amiodarone therapy were excluded. The association with and predictive impact on mortality were examined. Results: 36 (7.1%) patients had low-T3 syndrome. After adjustment for known confounders, NT-pro-BNP was significantly associated with fT3 and low-T3 syndrome. fT3 (HR 0.58, 95% CI 0.34-0.98) and low-T3 syndrome (HR 3.0, 95% CI 1.4-6.3) were predictive for mortality after adjustment for NT-pro-BNP levels and other cardiovascular prognostic variables. In patients with fT3 levels within the normal range, fT3 and NT-pro-BNP stratified by median values showed complementary prognostic information with the highest risk for mortality in patients with low normal fT3 and high NT-pro-BNP (HR 10.5, 95% CI 3.2-34.6). Conclusions: fT3 and low-T3 syndrome are significantly related to NT-pro-BNP in patients with cardiovascular disease, but are predictors of mortality independently of NT-pro-BNP and other known cardiovascular risk parameters. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Strack, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Wielckens, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Malchau, Gebhart UNSPECIFIED UNSPECIFIED UNSPECIFIED Erdmann, Erland UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Christian A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-494385
DOI:	10.1016/j.ijcard.2009.03.137
Journal or Publication Title:	Int. J. Cardiol.
Volume:	144
Number:	2
Page Range:	S. 187 - 191
Date:	2010
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	0167-5273
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRAIN NATRIURETIC PEPTIDE; CHRONIC HEART-FAILURE; THYROID-HORMONE METABOLISM; SICK EUTHYROID SYNDROME; MYOCARDIAL-INFARCTION; TRIIODOTHYRONINE; DISEASE; MORTALITY; ASSOCIATION; DYSFUNCTION Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49438