Universität zu Köln

Erren, Thomas C., Falaturi, Puran, Morfeld, Peter, Knauth, Peter, Reiter, Russel J. and Piekarski, Claus (2010). Shift Work and Cancer The Evidence and the Challenge. Dtsch. Arztebl. Int., 107 (38). S. 657 - 663. COLOGNE: DEUTSCHER AERZTE-VERLAG GMBH. ISSN 1866-0452

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Abstract

Background: In 2007, the International Agency for Research on Cancer (IARC) classified shift work with circadian disruption or chronodisruption as a probable human carcinogen. Short-term disturbances of biological 24-hour-rhythms following exposures to light and darkness at unusual times are well-known as jet-lag and shift-lag symptoms. However, that chronic disturbances or disruptions of timely sequenced circadian rhythms (chronodisruption) should contribute to long-term developments of cancer is a relatively new concept. This review provides background and practical information with regard to the open question does shift-work cause cancer? Methods: Overview on the basis of a selective literature search via Medline and ISI Web of Knowledge until 2009 from the viewpoints of occupational medicine, epidemiology, chronobiology, and occupational science. Results: The postulated causal links between shift-work and cancer in humans are biologically plausible in the light of experimental findings, but to date we lack epidemiological studies which could describe or exonerate risks in humans. Monetary compensation has already been paid for such cases in at least one country (Denmark). In Germany, however, according to the applicable law, a new occupational disease can only be recognized when certain conditions for the recognition of general scientific merit have been met. We present the current state of knowledge regarding prevention. Conclusion: While causal links between shift-work and cancer developments are not established, future shift-work planning should pay more attention to insights from occupational medicine, chronobiology, and occupational science.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Erren, Thomas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Falaturi, Puran UNSPECIFIED UNSPECIFIED UNSPECIFIED Morfeld, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Knauth, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Reiter, Russel J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Piekarski, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-496365
DOI:	10.3238/arztebl.2010.0657
Journal or Publication Title:	Dtsch. Arztebl. Int.
Volume:	107
Number:	38
Page Range:	S. 657 - 663
Date:	2010
Publisher:	DEUTSCHER AERZTE-VERLAG GMBH
Place of Publication:	COLOGNE
ISSN:	1866-0452
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BREAST-CANCER; VISUAL IMPAIRMENT; PROSTATE-CANCER; SLEEP DURATION; PROSPECTIVE COHORT; OHSAKI COHORT; RISK; CHRONODISRUPTION; FINLAND; WOMEN Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49636