Sievers, Hans-H, Stierle, Ulrich, Charitos, Efstratios I., Hanke, Thorsten, Misfeld, Martin, Bechtel, J. F. Matthias, Gorski, Armin, Franke, Ulrich F. W., Graf, Bernhard, Robinson, Derek R., Bogers, Ad J. J. C., Dodge-Khatami, Ali, Boehm, Juergen O., Rein, Joachim G., Botha, Cornelius A., Lange, Ruediger, Hoerer, Juergen, Moritz, Anton, Wahlers, Thorsten, Breuer, Martin, Ferrari-Kuehne, Katharina ORCID: 0000-0001-8928-8538, Hetzer, Roland, Huebler, Michael, Ziemer, Gerhard, Takkenberg, Johanna J. M. and Hemmer, Wolfgang (2010). Major Adverse Cardiac and Cerebrovascular Events After the Ross Procedure A Report From the German-Dutch Ross Registry. Circulation, 122 (11). S. S216 - 8. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1524-4539

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Abstract

Background-The purpose of the study is to report major cardiac and cerebrovascular events after the Ross procedure in the large adult and pediatric population of the German-Dutch Ross registry. These data could provide an additional basis for discussions among physicians and a source of information for patients. Methods and Results-One thousand six hundred twenty patients (1420 adults; 1211 male; mean age, 39.2+/-16.2 years) underwent a Ross procedure between 1988 and 2008. Follow-up was performed on an annual basis (median, 6.2 years; 10 747 patient-years). Early and late mortality were 1.2% (n=19) and 3.6% (n=58; 0.54%/patient-year), respectively. Ninety-three patients underwent 99 reinterventions on the autograft (0.92%/patient-year); 78 reinterventions in 63 patients on the pulmonary conduit were performed (0.73%/patient-year). Freedom from autograft or pulmonary conduit reoperation was 98.2%, 95.1%, and 89% at 1, 5, and 10 years, respectively. Preoperative aortic regurgitation and the root replacement technique without surgical autograft reinforcement were associated with a greater hazard for autograft reoperation. Major internal or external bleeding occurred in 17 (0.15%/patient-year), and a total of 38 patients had composite end point of thrombosis, embolism, or bleeding (0.35%/patient-year). Late endocarditis with medical (n=16) or surgical treatment (n=29) was observed in 38 patients (0.38%/patient-year). Freedom from any valve-related event was 94.9% at 1 year, 90.7% at 5 years, and 82.5% at 10 years. Conclusions-Although longer follow-up of patients who undergo Ross operation is needed, the present series confirms that the autograft procedure is a valid option to treat aortic valve disease in selected patients. The nonreinforced full root technique and preoperative aortic regurgitation are predictors for autograft failure and warrant further consideration.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sievers, Hans-HUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stierle, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Charitos, Efstratios I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanke, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Misfeld, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechtel, J. F. MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gorski, ArminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, Ulrich F. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graf, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robinson, Derek R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bogers, Ad J. J. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodge-Khatami, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehm, Juergen O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rein, Joachim G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Botha, Cornelius A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lange, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoerer, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moritz, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wahlers, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breuer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrari-Kuehne, KatharinaUNSPECIFIEDorcid.org/0000-0001-8928-8538UNSPECIFIED
Hetzer, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebler, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziemer, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Takkenberg, Johanna J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemmer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-496582
DOI: 10.1161/CIRCULATIONAHA.109.925800
Journal or Publication Title: Circulation
Volume: 122
Number: 11
Page Range: S. S216 - 8
Date: 2010
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1524-4539
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CRYOPRESERVED HOMOGRAFTS; ROOT REPLACEMENT; CHILDREN; OPERATION; PERFORMANCEMultiple languages
Cardiac & Cardiovascular Systems; Peripheral Vascular DiseaseMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/49658

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