Dadsena, Shashank ORCID: 0000-0002-0227-5900, King, Louise E ORCID: 0000-0003-2453-8887 and Garcia-Saez, Ana J. ORCID: 0000-0002-3894-5945 (2021). Apoptosis regulation at the mitochondria membrane level. Biochim Biophys Acta Biomembr, 12 (1863). p. 183716. Elsevier.

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Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis that activates the caspase cascade and irreversibly causes the majority of cells to die. The proteins of the Bcl-2 family are master regulators of apoptosis that form a complex interaction network within the mitochondrial membrane that determines the induction of MOMP. This culminates in the activation of the effector members Bax and Bak, which permeabilize the mitochondrial outer membrane to mediate MOMP. Although the key role of Bax and Bak has been established, many questions remain unresolved regarding molecular mechanisms that control the apoptotic pore. In this review, we discuss the recent progress in our understanding of the regulation of Bax/Bak activity within the mitochondrial membrane.

Item Type: Journal Article
CreatorsEmailORCIDORCID Put Code
King, Louise
Garcia-Saez, Ana
URN: urn:nbn:de:hbz:38-540610
DOI: 10.1016/j.bbamem.2021.183716
Journal or Publication Title: Biochim Biophys Acta Biomembr
Volume: 12
Number: 1863
Page Range: p. 183716
Date: 1 December 2021
Publisher: Elsevier
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases
Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: Life sciences
Related URLs:
Projects: ERC CoG GA No. 817758
Refereed: Yes


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