Universität zu Köln

Ottens, Franziska ORCID: 0000-0002-0353-2649, Franz, Andre and Hoppe, Thorsten (2021). Build-UPS and break-downs: metabolism impacts on proteostasis and aging. Cell Death Differ., 28 (2). S. 505 - 522. LONDON: SPRINGERNATURE. ISSN 1476-5403

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Abstract

Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular proteome and thus protein homeostasis (proteostasis). Consequently, changes in the cellular proteome due to metabolic shift require adaptive mechanisms by molecular protein quality control. The mechanisms vitally controlling proteostasis embrace the entire life cycle of a protein involving translational control at the ribosome, chaperone-assisted native folding, and subcellular sorting as well as proteolysis by the proteasome or autophagy. While metabolic imbalance and proteostasis decline have been recognized as hallmarks of aging and age-associated diseases, both processes are largely considered independently. Here, we delineate how proteome stability is governed by insulin/IGF1 signaling (IIS), mechanistic target of Rapamycin (TOR), 5 ' adenosine monophosphate-activated protein kinase (AMPK), and NAD-dependent deacetylases (Sir2-like proteins known as sirtuins). This comprehensive overview is emphasizing the regulatory interconnection between central metabolic pathways and proteostasis, indicating the relevance of shared signaling nodes as targets for future therapeutic interventions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ottens, Franziska UNSPECIFIED orcid.org/0000-0002-0353-2649 UNSPECIFIED Franz, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-563920
DOI:	10.1038/s41418-020-00682-y
Journal or Publication Title:	Cell Death Differ.
Volume:	28
Number:	2
Page Range:	S. 505 - 522
Date:	2021
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATED PROTEIN-KINASE; FOXO TRANSCRIPTION FACTORS; LIFE-SPAN EXTENSION; HEAT-SHOCK RESPONSE; UBIQUITIN-PROTEASOME SYSTEM; BOX-BINDING PROTEIN-1; STRESS-RESPONSE; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; SKELETAL-MUSCLE Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56392