Universität zu Köln

Schmidt, Thomas, Ghadimi, Markus, Fuchs, Hans F. and Bruns, Christiane J. (2022). Surgical and interdisciplinary treatment of gastrointestinal stromal tumors. Chirurg, 93 (1). S. 27 - 34. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0385

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Abstract

Gastrointestinal stromal tumors (GISTs) are the most frequent potentially malignant mesenchymal tumors of the gastrointestinal tract. The treatment of GISTs has been revolutionized since imatinib and other tyrosine kinase inhibitors were introduced for the treatment of GISTs, which inhibit the tyrosine kinases c-KIT and platelet-derived growth factor receptor (PDGFR) alpha. Even after the introduction of this targeted treatment GISTs can only be cured by surgical resection. With interdisciplinary multimodal treatment the prognosis of metastasized GIST can now be further improved by surgical resection of the primary tumor and the metastases, potentially leading to a cure. Neoadjuvant therapy can reduce the extent of surgical resection and hereby enable organ preservation and reduce surgical morbidity. To evaluate molecular and clinical predictors and to offer an optimal therapeutic plan, patients with GISTs and certainly patients with advanced GISTs should be evaluated by interdisciplinary sarcoma boards.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghadimi, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Hans F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-563971
DOI:	10.1007/s00104-021-01527-1
Journal or Publication Title:	Chirurg
Volume:	93
Number:	1
Page Range:	S. 27 - 34
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0385
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ITALIAN SARCOMA GROUP; PHASE-II TRIAL; NEOADJUVANT/ADJUVANT IMATINIB MESYLATE; TERM-FOLLOW-UP; ADJUVANT IMATINIB; RANDOMIZED-TRIAL; EUROPEAN ORGANIZATION; PROGNOSTIC-FACTORS; PROGRESSION-FREE; TYROSINE KINASE Multiple languages Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56397