Universität zu Köln

Filipovic, Karlo, Bellmann, Barbara, Sultan, Arian, Lueker, Jakob, Plenge, Tobias and Steven, Daniel (2021). Hydrochlorothiazide therapy: impact on early recurrence of atrial fibrillation after catheter ablation? Minerva Cardiol. Angiol., 69 (1). S. 102 - 109. TURIN: EDIZIONI MINERVA MEDICA. ISSN 2724-5772

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Abstract

BACKGROUND: Hypokalemia has been linked to electrocardiogram changes and after depolarization-mediated arrhythmias. However, the association between hypokalemia and atrial fibrillation (AF) has not been well studied. Hydrochlorothiazide (HCT) diuretic therapy was shown to be associated with hypokalemia in multiple studies. We aimed to determine whether HCT therapy is associated with early recurrence of AF after radiofrequency (RF) catheter ablation during a 3-month follow-up. METHODS: We performed a retrospective registry analysis of our internal AF ablation registry, containing 807 consecutive patients that underwent RF ablation for symptomatic AF. Propensity score matching was used to match 156 patients on HCT therapy with 156 controls. Furthermore, we performed propensity score matching between the first and the fourth quartile of baseline serum potassium (K) concentrations in the initial population (N.=807). RESULTS: We observed a small but statistically significant difference in baseline mean potassium levels between the HCT group and the control group (4.03 mmol/L vs. 4.19 mmol/L respectively, P=0.001). There was no difference in short term recurrence of atrial fibrillation in the HCT group compared to the propensity score matched control group (41.0% [N.=64] vs. 45.5% [N.=71], P=0.424). In the comparison between the first and the fourth quartile of baseline serum potassium values, no difference in AF recurrence (38.2% [N.=63] vs. 37.0% [N.=61], P=0.820) during a 3-month follow-up after ablation was observed between both groups. CONCLUSIONS: Patients on HCT therapy showed no difference in short term recurrence of AF after ablation compared to propensity matched controls.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Filipovic, Karlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Bellmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Sultan, Arian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueker, Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Plenge, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-564313
DOI:	10.23736/S2724-5683.20.05170-1
Journal or Publication Title:	Minerva Cardiol. Angiol.
Volume:	69
Number:	1
Page Range:	S. 102 - 109
Date:	2021
Publisher:	EDIZIONI MINERVA MEDICA
Place of Publication:	TURIN
ISSN:	2724-5772
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CALCIUM-CHANNEL BLOCKER; SERUM POTASSIUM LEVELS; OUTCOMES; RISK; HYPERTENSION; ARRHYTHMIAS; PREDICTION; DIURETICS; MORBIDITY; MORTALITY Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56431