Universität zu Köln

Persa, Oana D. and Mauch, Cornelia (2021). Outcomes after retreatment with MAPK inhibitors and immune checkpoint inhibitors in melanoma patients. Future Oncol., 17 (29). S. 3809 - 3818. LONDON: FUTURE MEDICINE LTD. ISSN 1744-8301

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Abstract

Background: When patients with advanced melanoma progress after MAPK inhibitor (MAPKI) and immune checkpoint inhibitor (ICI) treatment, they can either undergo chemotherapy or rechallenge with previously used treatments. Methods: The outcomes of 48 patients retreated with MAPKIs and 50 patients retreated with ICIs following progression were retrospectively analyzed. Results: Upon retreatment with MAPKIs, the disease control rate was 60%. Univariate analysis of possible risk factors associated with short progression-free survival upon MAPKI treatment showed elevated lactate dehydrogenase to be associated with decreased progression-free survival. Disease control rate after ICI retreatment was 24%. Melanoma of unknown primary was associated with prolonged progression-free survival upon ICI retreatment. Conclusion: Retreatment with MAPKIs or ICIs is a feasible option for patients with advanced melanoma. Lay abstract Targeted therapy and immunotherapy are standard treatments for advanced melanoma. Although this treatment often helps patients, at some point melanoma cells often find a way to continue growing despite treatment, which means that patients progress even with treatment. Once patients progress after both targeted therapy and immunotherapy, the physician is faced with the decision to restart a treatment to which melanoma cells may have become resistant or to switch the patient to chemotherapy. The aim of this study was to analyze outcomes after retreatment with targeted therapy and immunotherapy. The disease was controlled in 60% of 48 patients retreated with targeted therapy and in 24% of 50 patients retreated with immunotherapy, indicating that both are feasible options for melanoma retreatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Persa, Oana D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauch, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-564698
DOI:	10.2217/fon-2021-0446
Journal or Publication Title:	Future Oncol.
Volume:	17
Number:	29
Page Range:	S. 3809 - 3818
Date:	2021
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1744-8301
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METASTATIC MELANOMA; OPEN-LABEL; ANTI-CTLA-4; NIVOLUMAB; SAFETY; BRAF Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56469