Universität zu Köln

Herling, Marco and Braun, Till (2021). Tracing the roots of CLPD-NK by TET2 and STAT3. Blood, 137 (23). S. 3156 - 3160. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

In this issue of Blood, Pastoret et al present an immunophenotypic and genomic characterization of samples from 114 patients with suspected chronic lymphoproliferative disorders of natural killer cells (CLPD-NK). They report a high incidence of TET2 mutations, including the detection of these as a postulated precursor cell lesion in the myeloid compartment.(1) As a novel biologic and diagnostic hallmark of CLPD-NK, this finding provides a clinically useful marker for distinguishing CLPD-NK from reactive NK-cell expansions as well as for the discrimination of defined CLPD-NK subsets. The bilinear presence of TET2 variants substantiates existing epidemiological links between CLPD-NK and myeloid disorders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-566031
DOI:	10.1182/blood.2020010542
Journal or Publication Title:	Blood
Volume:	137
Number:	23
Page Range:	S. 3156 - 3160
Date:	2021
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLONAL HEMATOPOIESIS; MUTATIONS Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56603