Universität zu Köln

Gebehart, Corinna ORCID: 0000-0003-4426-6225, Schmidt, Joachim and Bueschges, Ansgar (2021). Distributed processing of load and movement feedback in the premotor network controlling an insect leg joint. J. Neurophysiol., 125 (5). S. 1800 - 1814. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1598

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Abstract

In legged animals, integration of information from various proprioceptors in and on the appendages by local premotor networks in the central nervous system is crucial for controlling motor output. To ensure posture maintenance and precise active movements, information about limb loading and movement is required. In insects, various groups of campaniform sensilla (CS) measure forces and loads acting in different directions on the leg, and the femoral chordotonal organ (fCO) provides information about movement of the femur-tibia (FTi) joint. In this study, we used extra- and intracellular recordings of extensor tibiae (ExtTi) and retractor coxae (RetCx) motor neurons (MNs) and identified local premotor nonspiking interneurons (NSIs) and mechanical stimulation of the fCO and tibial or trochanterofemoral CS (tiCS, tr/fCS), to investigate the premotor network architecture underlying multimodal proprioceptive integration. We found that load feedback from tiCS altered the strength of movement-elicited resistance reflexes and determined the specificity of ExtTi and RetCx MN responses to various load and movement stimuli. These responses were mediated by a common population of identified NSIs into which synaptic inputs from the fCO, tiCS, and tr/fCS are distributed, and whose effects onto ExtTi MNs can be antagonistic for both stimulus modalities. Multimodal sensory signal interaction was found at the level of single NSIs and MNs. The results provide evidence that load and movement feedback are integrated in a multimodal, distributed local premotor network consisting of antagonistic elements controlling movements of the FTi joint, thus substantially extending current knowledge on how legged motor systems achieve fine-tuned motor control. NEW & NOTEWORTHY Proprioception is crucial for motor control in legged animals. We show the extent to which processing of movement (fCO) and load (CS) signals overlaps in the local premotor network of an insect leg. Multimodal signals converge onto the same set of interneurons, and our knowledge about distributed, antagonistic processing is extended to incorporate multiple modalities within one perceptual neuronal framework.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gebehart, Corinna UNSPECIFIED orcid.org/0000-0003-4426-6225 UNSPECIFIED Schmidt, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Bueschges, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-566057
DOI:	10.1152/jn.00090.2021
Journal or Publication Title:	J. Neurophysiol.
Volume:	125
Number:	5
Page Range:	S. 1800 - 1814
Date:	2021
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1598
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONSPIKING LOCAL INTERNEURONS; TIBIAL CAMPANIFORM SENSILLA; FEMORAL CHORDOTONAL ORGAN; STICK INSECT; REFLEX PATHWAYS; MOTOR CONTROL; MULTISEGMENTAL COORDINATION; SENSORIMOTOR PATHWAYS; SHORTENING BEHAVIOR; MEDICINAL LEECH Multiple languages Neurosciences; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56605