Universität zu Köln

Ponnu, Jathish ORCID: 0000-0002-3276-7068 and Hoecker, Ute ORCID: 0000-0002-5636-9777 (2021). Illuminating the COP1/SPA Ubiquitin Ligase: Fresh Insights Into Its Structure and Functions During Plant Photomorphogenesis. Front. Plant Sci., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-462X

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Abstract

CONSTITUTIVE PHOTOMORPHOGENIC 1 functions as an E3 ubiquitin ligase in plants and animals. Discovered originally in Arabidopsis thaliana, COP1 acts in a complex with SPA proteins as a central repressor of light-mediated responses in plants. By ubiquitinating and promoting the degradation of several substrates, COP1/SPA regulates many aspects of plant growth, development and metabolism. In contrast to plants, human COP1 acts as a crucial regulator of tumorigenesis. In this review, we discuss the recent important findings in COP1/SPA research including a brief comparison between COP1 activity in plants and humans.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ponnu, Jathish UNSPECIFIED orcid.org/0000-0002-3276-7068 UNSPECIFIED Hoecker, Ute UNSPECIFIED orcid.org/0000-0002-5636-9777 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-566075
DOI:	10.3389/fpls.2021.662793
Journal or Publication Title:	Front. Plant Sci.
Volume:	12
Date:	2021
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-462X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-BOX PROTEIN; INHIBITS COP1-MEDIATED DEGRADATION; LIGHT-DEPENDENT INTERACTION; RING FINGER MOTIF; TRANSCRIPTION FACTOR; ARABIDOPSIS COP1; GENE-EXPRESSION; SPA PROTEINS; E3 LIGASE; NEGATIVE REGULATOR Multiple languages Plant Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56607