Universität zu Köln

Iuga, Andra-Iza, Pennig, Lenhard, Caldeira, Liliana Lourenco, Maintz, David, Hickethier, Tilman and Doerner, Jonas (2021). Prediction of anemia on enhanced computed tomography of the thorax using virtual non-contrast reconstructions. Medicine (Baltimore), 100 (48). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-5964

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Abstract

To determine if anemia can be predicted on enhanced computed tomography (CT) examinations of the thorax using virtual non-contrast (VNC) images, in order to support clinicians especially in diagnosing primary asymptomatic patients in daily routine. In this monocentric study, 100 consecutive patients (50 with proven anemia), who underwent a contrast-enhanced CT examination of the thorax due to various indications were included. Attenuation was measured in the descending thoracic aorta, the intraventricular septum, and the left ventricle cavity both in the conventional contrast-enhanced and in the VNC images. Two experienced radiologists annotated the delineation of a dense interventricular septum or a hyperattenuating aortic wall sign for all patients. Hemoglobin levels were then correlated with the measured attenuation values, as well as the visualization of the aortic wall or interventricular septum. Good correlation was shown between hemoglobin levels and CT attenuation values of the left ventricular cavity (r = .59), aorta (r = .56), and ratio between left ventricular cavity and the intraventricular septum (r = .57). Receiver operating characteristic curve revealed <= 36.5 hounsfield units (left ventricular cavity) as the threshold for diagnosing anemia. Predicting anemia by visualization of a hyperattenuating aortic wall or a dense interventricular septum yielded a specificity of 98% and 92%, respectively. Predicting anemia on enhanced CT examinations using VNC is feasible. A threshold value of <= 36.5 hounsfield units (left ventricular cavity) best defines anemia. Aortic wall or interventricular septum visualization on VNC is a specific anemia indicator.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Iuga, Andra-Iza UNSPECIFIED UNSPECIFIED UNSPECIFIED Pennig, Lenhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Caldeira, Liliana Lourenco UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Hickethier, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerner, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-567700
DOI:	10.1097/MD.0000000000028014
Journal or Publication Title:	Medicine (Baltimore)
Volume:	100
Number:	48
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-5964
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INCIDENTAL FINDINGS; CT Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56770