Universität zu Köln

Rill, Constantin, Scheerer, Lukas, Iorgu, Ana-Maria and Bonmann, Eckhard (2021). A beta-related Angiitis (ABRA)-A Rare Paraneoplastic Cause of Cerebral Vasculitis in a Young Patient A Pathway From Unspecific Neurological Symptoms to Final Diagnosis. Neurologist, 26 (3). S. 103 - 108. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2331-2637

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Abstract

Introduction: A beta-related angiitis (ABRA) is a very rare disease entity with combined features of cerebral amyloid angiopathy and primary angiitis of the CNS. However, the pathogenesis has not been conclusively described yet. Interestingly though, a possible paraneoplastic origin has been reported in the past. ABRA leads to severe encephalopathy with a broad spectrum of unspecific neurological symptoms and usually occurs in older patients. Because of the response to immunological treatment, it is important to confirm the diagnosis as fast as possible. Unfortunately, the pathway to a definite diagnosis is often complicated and prolonged. Case Report: Here, we describe a 48-year-old-female patient presenting headache, behavioral changes as well as subacute fatigue and epileptic seizures in the recent past. The initial neuroradiological examination demonstrated extended lesions in the left hemisphere compatible with an inflammatory or neoplastic disease. After extensive investigations, initially without a definite result, we finally validated the diagnosis of ABRA by brain biopsy. Shortly afterwards a routine check-up revealed an invasive mammary carcinoma. Owing to a mandatory mastectomy and chemotherapy, an immunosuppressive therapy was not implemented. Conclusions: The reported case demonstrates our diagnostic approach and the clinical difficulties in validating a rare cause of encephalopathy in a young patient with nonspecific clinical and neuroradiological findings. Because of the possibility of an effective treatment, it is important to consider ABRA in the differential diagnosis especially when blood tests, analysis of cerebrospinal fluid, and angiography show normal results. Since a paraneoplastic genesis is presumed, a search for an underlying tumor disease should be considered.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rill, Constantin UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheerer, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Iorgu, Ana-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonmann, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-569062
DOI:	10.1097/NRL.0000000000000316
Journal or Publication Title:	Neurologist
Volume:	26
Number:	3
Page Range:	S. 103 - 108
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	2331-2637
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AMYLOID ANGIOPATHY; INFLAMMATION; CAA Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56906