Universität zu Köln

Drozhzhyna, Galyna, Gaidamaka, Tetiana Borisovna, Cursiefen, Claus, Bachmann, Bjorn O., Matthaei, Mario, Siebelmann, Sebastian, Ostashevsky, Viktor, Ivanovska, Olena, V and Kogan, Boris M. (2021). Efficient Use of Corneal Grafts through Multimodal Donor Tissue Splitting. Klinische Monatsblat. Augenheilkunde, 238 (10). S. 1120 - 1128. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

Background The reduced availability of corneal donor tissue in Ukraine requires the most effective use of the available grafts. The present work describes and evaluates a method to obtain several small diameter corneal grafts from a single donor cornea (multimodal donor tissue splitting). Material and Methods This retrospective cohort study includes keratoplasty procedures performed at the Department of Corneal Pathology, State Institution, The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine, Odessa, Ukraine. The method of graft preparation includes either lamellar dissection of the entire graft or partial lamellar dissection to obtain two lamellar and/or full-thickness grafts. Grafts were not only cut in a circular manner, but the individual shape was also adjusted to match the shape of non-circular corneal defects. Results A total of 324 keratoplasties between January 2016 and December 2017, using 270 grafts, were included. In 54 cases (including 34 emergency situations), one transplant was used for two recipients. Of these, 43 were therapeutic keratoplasties and 11 peripheral lamellar keratoplasties due to grade III-IV recurrent pterygia. In two cases, two grafts for one patient were dissected from a single donor cornea. Out of 43 patients with curative keratoplasty, visual acuity improved in 28 eyes (65.1%) or remained unchanged in 15 eyes (34.9%). Postoperative visual acuity was dependent on the initial state of the eye, the localisation, the depth and the area of the corneal defect. In eyes with peripheral corneal localisation of ulcerations, even in the presence of corneal perforation, good functional results were obtained. Conclusion If two or more grafts are obtained from a single donor cornea for different kinds of keratoplasty procedures, this reduces the need for corneal graft tissue and, consequently, the cost of preservation. Especially in regions with a high shortage of donor tissue, this provides additional tissue capacities for emergency situations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Drozhzhyna, Galyna UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaidamaka, Tetiana Borisovna UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjorn O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebelmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostashevsky, Viktor UNSPECIFIED UNSPECIFIED UNSPECIFIED Ivanovska, Olena, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Kogan, Boris M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-570134
DOI:	10.1055/a-1165-2134
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	238
Number:	10
Page Range:	S. 1120 - 1128
Date:	2021
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LAMELLAR KERATOPLASTY; VISUAL IMPAIRMENT; TRANSPLANTATION; RECIPIENTS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57013