Universität zu Köln

Mesa-Galloso, Haydee, Pedrera, Lohans and Ros, Uris (2021). Pore-forming proteins: From defense factors to endogenous executors of cell death. Chem. Phys. Lipids, 234. CLARE: ELSEVIER IRELAND LTD. ISSN 1873-2941

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Abstract

Pore-forming proteins (PFPs) and small antimicrobial peptides (AMPs) represent a large family of molecules with the common ability to punch holes in cell membranes to alter their permeability. They play a fundamental role as infectious bacteria's defensive tools against host's immune system and as executors of endogenous machineries of regulated cell death in eukaryotic cells. Despite being highly divergent in primary sequence and 3D structure, specific folds of pore-forming domains have been conserved. In fact, pore formation is considered an ancient mechanism that takes place through a general multistep process involving: membrane partitioning and insertion, oligomerization and pore formation. However, different PFPs and AMPs assemble and form pores following different mechanisms that could end up either in the formation of protein-lined or protein-lipid pores. In this review, we analyze the current findings in the mechanism of action of different PFPs and AMPs that support a wide role of membrane pore formation in nature. We also provide the newest insights into the development of state-of-art techniques that have facilitated the characterization of membrane pores. To understand the physiological role of these peptides/proteins or develop clinical applications, it is essential to uncover the molecular mechanism of how they perforate membranes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mesa-Galloso, Haydee UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedrera, Lohans UNSPECIFIED UNSPECIFIED UNSPECIFIED Ros, Uris UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-570288
DOI:	10.1016/j.chemphyslip.2020.105026
Journal or Publication Title:	Chem. Phys. Lipids
Volume:	234
Date:	2021
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1873-2941
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUPPORTED LIPID-BILAYERS; ATOMIC-FORCE MICROSCOPY; CHOLESTEROL-DEPENDENT CYTOLYSINS; MOLECULAR-DYNAMICS SIMULATIONS; ANTIMICROBIAL PEPTIDE ACTION; STUDYING MEMBRANE-PROTEINS; SEA-ANEMONE ACTINOPORINS; ALL-OR-NONE; CRYSTAL-STRUCTURE; PLASMA-MEMBRANE Multiple languages Biochemistry & Molecular Biology; Biophysics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57028