Universität zu Köln

Sprute, Rosanne ORCID: 0000-0003-2457-6437, Schumacher, Sofie, Pauls, Martina, Pauls, Wolfgang and Cornely, Oliver A. (2021). Delayed Cutaneous Hypersensitivity Reaction to Vaxzevria (ChAdOx1-S) Vaccine against SARS-CoV-2. Drugs R&D, 21 (4). S. 371 - 375. CHAM: SPRINGER INT PUBL AG. ISSN 1179-6901

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Abstract

Recently, an increasing number of cases with delayed cutaneous reaction after immunization with mRNA-based vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. This adverse reaction, which is considered a delayed-type or T cell-mediated hypersensitivity reaction, has been described for the Moderna (mRNA-1273) and Comirnaty (Pfizer/BioNTech, BNT162b2) vaccines. We describe a delayed large local cutaneous reaction in a patient who received the viral vector vaccine Vaxzevria (ChAdOx1-S, AstraZeneca). The time course and clinical symptoms of delayed skin reaction after mRNA vaccines have a similar pattern that we recognized in our patient after Vaxzevria vaccination. This phenomenon has not been described in the Vaxzevria clinical trials and is to our knowledge the first report of this adverse reaction to a vector-based SARS-CoV-2 vaccine. With this, we hope to raise awareness about delayed injection site reactions that also occur after viral vector vaccines and to encourage additional reporting and patient education regarding the cutaneous reactions after coronavirus disease 2019 (COVID-19) vaccination.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sprute, Rosanne UNSPECIFIED orcid.org/0000-0003-2457-6437 UNSPECIFIED Schumacher, Sofie UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauls, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauls, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-570317
DOI:	10.1007/s40268-021-00358-z
Journal or Publication Title:	Drugs R&D
Volume:	21
Number:	4
Page Range:	S. 371 - 375
Date:	2021
Publisher:	SPRINGER INT PUBL AG
Place of Publication:	CHAM
ISSN:	1179-6901
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COVID-19 VACCINATION Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57031