Schreiber, Tina, Brockmann, Michael, Gossmann, Axel, Kosse, Nils Juriaan, Stoelben, Erich and Windisch, Wolfram (2021). SARCOIDOSIS INVOLVEMENT OF THE DIAPHRAGM LEADING TO RIGHT DIAPHRAGMATIC ELEVATION: A CASE REPORT. Sarcoidosis Vasc. Diffus. Lung Dis., 38 (2). FIDENZA: MATTIOLI 1885. ISSN 1124-0490
Full text not available from this repository.Abstract
A 69-year-old male Caucasian presenting with dyspnea on exertion related to unilateral diaphragmatic dysfunction as caused by sarcoidosis is described. First, right diaphragmatic elevation was unexplained, while the patient presented with a restrictive pattern in lung function testing using bodyplethysmography and with reduced global and diaphragmatic respiratory muscle strength as evidenced by respiratory pressures. Subsequently, surgical diaphragm plication was performed, unfortunately, without any clinical improvement. Microscopic examination of diaphragm sections revealed a lymphocytic myositis with granulomatous pleuritis showing multiple non-caseating epithelioid granulomas. Accordingly, a lymphocytic alveolitis (26% lymphocytes) with an elevated CD4/CD8 T cell ratio of 8.0% and elevated serum parameters (neopterin and sIL-2 receptor) were established. Consequently, the diagnosis of pulmonary sarcoidosis with diaphragm involvement but without extrapulmonary involvement has been established. Therefore, sarcoidosis needs to be considered in any patient presenting with unilateral diaphragmatic dysfunction. The optimal treatment strategy, however, needs to be established in the future.
Item Type: | Journal Article | ||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-570416 | ||||||||||||||||||||||||||||
DOI: | 10.36141/svdld.v38i2.8042 | ||||||||||||||||||||||||||||
Journal or Publication Title: | Sarcoidosis Vasc. Diffus. Lung Dis. | ||||||||||||||||||||||||||||
Volume: | 38 | ||||||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||||||
Date: | 2021 | ||||||||||||||||||||||||||||
Publisher: | MATTIOLI 1885 | ||||||||||||||||||||||||||||
Place of Publication: | FIDENZA | ||||||||||||||||||||||||||||
ISSN: | 1124-0490 | ||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/57041 |
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