Dadsena, Shashank ORCID: 0000-0002-0227-5900, Jenner, Andreas and Garcia-Saez, Ana J. (2021). Mitochondrial outer membrane permeabilization at the single molecule level. Cell. Mol. Life Sci., 78 (8). S. 3777 - 3791. BASEL: SPRINGER BASEL AG. ISSN 1420-9071
Full text not available from this repository.Abstract
Apoptotic cell death is essential for development, immune function or tissue homeostasis, and its mis-regulation is linked to various diseases. Mitochondrial outer membrane permeabilization (MOMP) is a central event in the intrinsic apoptotic pathway and essential to control the execution of cell death. Here we review current concepts in regulation of MOMP focusing on the interaction network of the Bcl-2 family proteins as well as further regulatory elements influencing MOMP. As MOMP is a complex spatially and temporally controlled process, we point out the importance of single-molecule techniques to unveil processes which would be masked by ensemble measurements. We report key single-molecule studies applied to decipher the composition, assembly mechanism and structure of protein complexes involved in MOMP regulation.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-571332 | ||||||||||||||||
DOI: | 10.1007/s00018-021-03771-4 | ||||||||||||||||
Journal or Publication Title: | Cell. Mol. Life Sci. | ||||||||||||||||
Volume: | 78 | ||||||||||||||||
Number: | 8 | ||||||||||||||||
Page Range: | S. 3777 - 3791 | ||||||||||||||||
Date: | 2021 | ||||||||||||||||
Publisher: | SPRINGER BASEL AG | ||||||||||||||||
Place of Publication: | BASEL | ||||||||||||||||
ISSN: | 1420-9071 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/57133 |
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