Dadsena, Shashank ORCID: 0000-0002-0227-5900, Jenner, Andreas and Garcia-Saez, Ana J. (2021). Mitochondrial outer membrane permeabilization at the single molecule level. Cell. Mol. Life Sci., 78 (8). S. 3777 - 3791. BASEL: SPRINGER BASEL AG. ISSN 1420-9071

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Abstract

Apoptotic cell death is essential for development, immune function or tissue homeostasis, and its mis-regulation is linked to various diseases. Mitochondrial outer membrane permeabilization (MOMP) is a central event in the intrinsic apoptotic pathway and essential to control the execution of cell death. Here we review current concepts in regulation of MOMP focusing on the interaction network of the Bcl-2 family proteins as well as further regulatory elements influencing MOMP. As MOMP is a complex spatially and temporally controlled process, we point out the importance of single-molecule techniques to unveil processes which would be masked by ensemble measurements. We report key single-molecule studies applied to decipher the composition, assembly mechanism and structure of protein complexes involved in MOMP regulation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dadsena, ShashankUNSPECIFIEDorcid.org/0000-0002-0227-5900UNSPECIFIED
Jenner, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Saez, Ana J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-571332
DOI: 10.1007/s00018-021-03771-4
Journal or Publication Title: Cell. Mol. Life Sci.
Volume: 78
Number: 8
Page Range: S. 3777 - 3791
Date: 2021
Publisher: SPRINGER BASEL AG
Place of Publication: BASEL
ISSN: 1420-9071
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57133

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