Hoyer-Allo, Karla Johanna Ruth, Spaeth, Martin Richard, Hanssen, Ruth, Johnsen, Marc, Brodesser, Susanne, Kaufmann, Kathrin, Kiefer, Katharina ORCID: 0000-0003-3812-217X, Koehler, Felix Carlo ORCID: 0000-0001-9269-7420, Goebel, Heike, Kubacki, Torsten, Grundmann, Franziska ORCID: 0000-0002-5766-7477, Schermer, Bernhard, Bruening, Jens, Benzing, Thomas, Burst, Volker ORCID: 0000-0002-0256-6628 and Mueller, Roman-Ulrich (2021). Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. Int. J. Mol. Sci., 22 (11). BASEL: MDPI. ISSN 1422-0067

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Abstract

Acute kidney injury (AKI) is a frequent and critical complication in the clinical setting. In rodents, AKI can be effectively prevented through caloric restriction (CR), which has also been shown to increase lifespan in many species. In Caenorhabditis elegans (C. elegans), longevity studies revealed that a marked CR-induced reduction of endocannabinoids may be a key mechanism. Thus, we hypothesized that regulation of endocannabinoids, particularly arachidonoyl ethanolamide (AEA), might also play a role in CR-mediated protection from renal ischemia-reperfusion injury (IRI) in mammals including humans. In male C57Bl6J mice, CR significantly reduced renal IRI and led to a significant decrease of AEA. Supplementation of AEA to near-normal serum concentrations by repetitive intraperitoneal administration in CR mice, however, did not abrogate the protective effect of CR. We also analyzed serum samples taken before and after CR from patients of three different pilot trials of dietary interventions. In contrast to mice and C. elegans, we detected an increase of AEA. We conclude that endocannabinoid levels in mice are modulated by CR, but CR-mediated renal protection does not depend on this effect. Moreover, our results indicate that modulation of endocannabinoids by CR in humans may differ fundamentally from the effects in animal models.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hoyer-Allo, Karla Johanna RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spaeth, Martin RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanssen, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnsen, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brodesser, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaufmann, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiefer, KatharinaUNSPECIFIEDorcid.org/0000-0003-3812-217XUNSPECIFIED
Koehler, Felix CarloUNSPECIFIEDorcid.org/0000-0001-9269-7420UNSPECIFIED
Goebel, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kubacki, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grundmann, FranziskaUNSPECIFIEDorcid.org/0000-0002-5766-7477UNSPECIFIED
Schermer, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruening, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benzing, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burst, VolkerUNSPECIFIEDorcid.org/0000-0002-0256-6628UNSPECIFIED
Mueller, Roman-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-572033
DOI: 10.3390/ijms22115485
Journal or Publication Title: Int. J. Mol. Sci.
Volume: 22
Number: 11
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 1422-0067
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CANNABINOID RECEPTORS; REPERFUSION INJURY; MOUSE MODEL; SYSTEM; ANANDAMIDE; ISCHEMIA; IMPACT; INFLAMMATION; ACTIVATION; OUTCOMESMultiple languages
Biochemistry & Molecular Biology; Chemistry, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57203

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