Universität zu Köln

Li, Mengnan and Iden, Sandra ORCID: 0000-0003-2333-9827 (2021). Emerging Laminin-332-Dependent and -Independent Roles for Integrin alpha 3 in Protumorigenic Signaling. J. Invest. Dermatol., 141 (4). S. 713 - 717. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1747

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Abstract

The epidermal integrin alpha 3 beta 1 promotes skin tumorigenesis in experimental models; yet, the underlying molecular mechanisms remain mostly unclear. In their article, Ramovs et al. (2020a) identify two spatially separated alpha 3 beta 1-dependent signaling branches fostering skin tumor outgrowth. In basal keratinocytes, alpha 3 beta 1/laminin (LN)-332 drives FAK/Src activation, whereas in suprabasal layers, junctional alpha 3 beta 1 and the tetraspanin CD151 mediate signal transducer and protein kinase B (Akt).dependent survival that is independent of LN-332 binding.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Mengnan UNSPECIFIED UNSPECIFIED UNSPECIFIED Iden, Sandra UNSPECIFIED orcid.org/0000-0003-2333-9827 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572245
DOI:	10.1016/j.jid.2020.08.017
Journal or Publication Title:	J. Invest. Dermatol.
Volume:	141
Number:	4
Page Range:	S. 713 - 717
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-1747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57224