Universität zu Köln

Herling, Marco and Wahnschaffe, Linus (2021). Altered epigenetics at the center of NK-LGL leukemia. Blood, 138 (8). S. 589 - 592. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

In this issue of Blood, Olson et al describe (epi)genetic changes in 58 patients with chronic natural killer large granular lymphocyte (NK-LGL) leukemia, uncovering recurrent loss-of function mutations in the TET2 gene. They highlight the associations of these lesions with altered global patterns of DNA methylation, with distinct cytopenias, and with treatment responses. This significantly adds to our understanding of the pathogenesis of and diagnostic approach to this rare disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahnschaffe, Linus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572361
DOI:	10.1182/blood.2021011875
Journal or Publication Title:	Blood
Volume:	138
Number:	8
Page Range:	S. 589 - 592
Date:	2021
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TET2 MUTATIONS; APOPTOSIS; STAT3 Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57236