Universität zu Köln

Maehringer-Kunz, Aline, Meyer, Franziska I., Hahn, Felix, Mueller, Lukas, Dueber, Christoph, Pinto Dos Santos, Daniel, Galle, Peter R., Weinmann, Arndt ORCID: 0000-0003-1198-1716, Kloeckner, Roman ORCID: 0000-0001-5492-4792 and Schotten, Sebastian (2021). Hepatic vein tumor thrombosis in patients with hepatocellular carcinoma: Prevalence and clinical significance. United European Gastroenterol. J., 9 (5). S. 590 - 598. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 2050-6414

Full text not available from this repository.

Abstract

Background There is strong evidence that portal vein tumor thrombosis (PVTT) is associated with poor survival in patients with hepatocellular carcinoma (HCC). However, data regarding the clinical significance of hepatic vein tumor thrombosis (HVTT) is rare, particularly in Western patients. Objective To determine the HVTT prevalence in a Western patient population and its impact on survival. Methods We included 1310 patients with HCC treated in our tertiary referral center between January 2005 and December 2016. HVTT and PVTT were diagnosed with contrast-enhanced cross-sectional imaging. Overall survival (OS) was calculated starting from the initial HCC diagnosis, and in a second step, starting from the first appearance of vascular invasion. Results We observed macrovascular invasion (MVI) in 519 patients who suffered from either isolated HVTT (n = 40), isolated PVTT (n = 352), or both combined (HVTT + PVTT) (n = 127). Calculated from the initial HCC diagnosis, the median OS for patients with isolated HVTT was significantly shorter than that of patients without MVI (13.3 vs. 32.5 months, p < 0.001). Calculated from the first appearance of MVI, the median OS was similar among patients with isolated HVTT (6.5 months), isolated PVTT (5 months), and HVTT + PVTT (5 months). Multivariate analysis confirmed HVTT as an independent risk factor for poor survival. Conclusions HVTT may be more common than typically reported. In most patients, it was accompanied by PVTT. Isolated HVTT occurred less frequently and later than isolated PVTT; however, once developed, it had the same deleterious impact on survival. Therefore, patients with HVTT should be classified as advanced stage of HCC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maehringer-Kunz, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Franziska I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dueber, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Pinto Dos Santos, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Galle, Peter R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinmann, Arndt UNSPECIFIED orcid.org/0000-0003-1198-1716 UNSPECIFIED Kloeckner, Roman UNSPECIFIED orcid.org/0000-0001-5492-4792 UNSPECIFIED Schotten, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572971
DOI:	10.1002/ueg2.12098
Journal or Publication Title:	United European Gastroenterol. J.
Volume:	9
Number:	5
Page Range:	S. 590 - 598
Date:	2021
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	2050-6414
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; PRIMARY LIVER-CANCER; FOLLOW-UP SURVEY; PORTAL-VEIN; TRANSARTERIAL CHEMOEMBOLIZATION; BLAND; DIFFERENTIATION; PATHOLOGY; RESECTION; SURVIVAL Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57297