Universität zu Köln

Keidel, Leonie F., Zwingelberg, Sarah, Schworm, Benedikt, Luft, Nikolaus, Herold, Tina, Priglinger, Siegfried G. and Siedlecki, Jakob (2021). Pachychoroid disease and its association with retinal vein occlusion: a case-control study. Sci Rep, 11 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

The development of a retinal vein occlusion (RVO) is multifactorial. This study investigates pachychoroid as a risk factor for RVO or as an entity sharing common pathophysiology with RVO. A database screening at the University Eye Hospital, Ludwig-Maximilian University Munich, Germany was performed for patients diagnosed with central or branch RVO (CRVO/BRVO). In every patient a complete ophthalmologic examination was performed, including posterior segment enhanced depth spectral domain optical coherence tomography (EDI-SD-OCT). The SD-OCT scans of respective partner eyes without history of RVO were compared to an age- and refraction-matched, randomly recruited normal control group. In total, 312 eyes of 312 patients were included in this study, with 162 eyes in the RVO and 150 eyes in the control group. A significantly higher subfoveal choroidal thickness (SFCT) was found in the RVO (310.3 +/- 72.5 (94 to 583) mu m) as compared to the control group (237.0 +/- 99.0 (62 to 498); p < 0.00001). Moreover, the RVO group showed a significantly higher prevalence of a symptomatic pachychoroid (22 vs. 9 eyes; odds ratio: 2.46; 95 CI: 1.10 to 5.53; p = 0.029). Since pachychoroid disease represents a bilateral entity, it might be a risk factor for RVO, or share risk factors with RVO.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Keidel, Leonie F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zwingelberg, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Schworm, Benedikt UNSPECIFIED UNSPECIFIED UNSPECIFIED Luft, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Herold, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Priglinger, Siegfried G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Siedlecki, Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-573474
DOI:	10.1038/s41598-021-99115-0
Journal or Publication Title:	Sci Rep
Volume:	11
Number:	1
Date:	2021
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHOROIDAL BLOOD-FLOW; THICKNESS; SECONDARY; THERAPY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57347