Universität zu Köln

Gouveia, Ayden, de Oliveira Beleza, Rui and Steculorum, Sophie M. (2021). AgRP neuronal activity across feeding-related behaviours. Eur. J. Neurosci., 54 (10). S. 7458 - 7476. HOBOKEN: WILEY. ISSN 1460-9568

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Abstract

AgRP neurons trigger one of the most potent orexigenic responses and are both necessary and sufficient for feeding. Recent technical advances for monitoring in vivo neuronal activity have revisited a previously well-established model of AgRP neurons' feeding regulatory effects. Our current understanding of AgRP neurons has increased in complexity and revealed a fine-tuned regulation of their activity dynamics across the whole sequence of feeding-related behaviours. This review focuses on recent studies that refined and re-evaluated our understanding of the regulatory principles and behavioural effects of AgRP circuits. We aim to cover major discoveries on the dynamic regulation of AgRP neuronal activity by exteroceptive and interoceptive food-related cues, their pleiotropic effects in feeding and whole-body homeostasis, and the associated AgRP circuits. The function and regulation of AgRP neuron will be sequentially discussed across the temporal series of behavioural and physiological changes occurring during the appetitive (food craving and foraging), the anticipatory (discovery of food-predicting cues), and the consummatory/post-ingestive phase of feeding (calorie ingestion).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gouveia, Ayden UNSPECIFIED UNSPECIFIED UNSPECIFIED de Oliveira Beleza, Rui UNSPECIFIED UNSPECIFIED UNSPECIFIED Steculorum, Sophie M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-574253
DOI:	10.1111/ejn.15498
Journal or Publication Title:	Eur. J. Neurosci.
Volume:	54
Number:	10
Page Range:	S. 7458 - 7476
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1460-9568
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEURAL CIRCUIT; EXPRESSING NEURONS; ARCUATE NUCLEUS; HUNGER; SUPPRESSION; APPETITE; LEPTIN; MICE; INTERROGATION; STIMULATION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57425