Universität zu Köln

Hopff, Sina M., Onambele, Liliane A., Brandenburg, Marc, Berkessel, Albrecht and Prokop, Aram (2021). Sensitizing multidrug-resistant leukemia cells to common cytostatics by an aluminium-salen complex that has high-apoptotic effects in leukemia, lymphoma and mamma carcinoma cells. Biometals, 34 (2). S. 211 - 221. DORDRECHT: SPRINGER. ISSN 1572-8773

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Abstract

We investigated the aluminium-salen complex MBR-8 as a potential anti-cancer agent. To see apoptotic effects induced by MBR-8, alone and in combination with common cytostatic drugs, DNA-fragmentations were studied using the flow cytometric analysis. Western blot analysis and measurement of the mitochondrial membrane potential with a JC-1 dye were employed to identify the pathway of apoptosis. An impressive overcoming of multidrug-resistance in leukemia (Nalm6) cells was observed. Additionally, solid tumor cells including Burkitt-like lymphoma (BJAB) and mamma carcinoma cells (MCF-7) are affected by MBR-8 in the same way. Western blot analysis revealed activation of caspase-3. MBR-8 showed very pronounced selectivity with regard to tumor cells and high synergistic effects in Nalm6 and daunorubicin-resistant Nalm6 cells when administered in combination with vincristine, daunorubicin and doxorubicin. The aluminium-salen complex MBR-8 showed very promising anti-cancer properties which warrant further development towards a cytostatic agent for future chemotherapy. Studies on aluminium compounds for cancer therapy are rare, and our report adds to this important body of knowledge.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hopff, Sina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Onambele, Liliane A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandenburg, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Berkessel, Albrecht UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokop, Aram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-575080
DOI:	10.1007/s10534-020-00273-x
Journal or Publication Title:	Biometals
Volume:	34
Number:	2
Page Range:	S. 211 - 221
Date:	2021
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1572-8773
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57508