Universität zu Köln

Koerber, Friederike and Schaefer, Jurgen Frank (2021). Radiological imaging of neuroblastoma. Radiologe, 61 (7). S. 639 - 649. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-2102

Full text not available from this repository.

Abstract

Background Neuroblastomas are tumors of the sympathetic nervous system that arise from the sympathetic trunk and adrenal glands. Tissue compositions, molecular genetics, and overall prognosis are heterogeneous. With an incidence of 1:6000, neuroblastomas account for 5.5% of childhood tumors. They usually occur in children up to preschool age with the mean age of 14 months. Adults are very rarely affected. Imaging, especially magnetic resonance imaging (MRI), plays an essential role in diagnosis, risk stratification, and therapy control. Materials and methods Based on a selective literature search in the PubMed database, the national and international societies' guidelines and study protocols, the imaging standards and the latest developments are presented. Conclusion Imaging plays a key role in neuroblastomas due to the heterogeneous prognosis and the resulting very different therapy. A high degree of standardization in implementation and interpretation is important in every phase of the disease process. Sonography, MRI with diffusion weighting, and I-123-mIBG-SPECT are essential modalities. The extent of the diffusion restriction for assessing the degree of maturity and assessing the therapeutic response is becoming increasingly important in clinical routine. Up to now, PET imaging has mostly been complementary. Newly developed PET tracers promise comprehensive diagnostics and may also play a major role in theranostics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koerber, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Jurgen Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-575179
DOI:	10.1007/s00117-021-00875-7
Journal or Publication Title:	Radiologe
Volume:	61
Number:	7
Page Range:	S. 639 - 649
Date:	2021
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-2102
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPSOCLONUS-MYOCLONUS SYNDROME; HIGH-RISK NEUROBLASTOMA; DIFFUSION-WEIGHTED MRI; WHOLE-BODY MRI; PEDIATRIC-PATIENTS; DIAGNOSTIC-VALUE; PET/CT; METAIODOBENZYLGUANIDINE; DIFFERENTIATION; STRATIFICATION Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57517