Universität zu Köln

Hanisch, Franz-Georg ORCID: 0000-0003-3619-7039, Aydogan, Cem and Schroten, Horst (2021). Fucoidan and Derived Oligo-Fucoses: Structural Features with Relevance in Competitive Inhibition of Gastrointestinal Norovirus Binding. Mar. Drugs, 19 (11). BASEL: MDPI. ISSN 1660-3397

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Abstract

Norovirus infections belong to the most common causes of human gastroenteritis worldwide and epidemic outbreaks are responsible for hundreds of thousands of deaths annually. In humans, noroviruses are known to bind to gastrointestinal epithelia via recognition of blood-group active mucin-type O-glycans. Considering the involvement of l-alpha-fucose residues in these glycans, their high valency on epithelial surfaces far surpasses the low affinity, though specific interactions of monovalent milk oligosaccharides. Based on these findings, we attempted to identify polyfucoses (fucans) with the capacity to block binding of the currently most prevalent norovirus strain GII.4 (Sydney, 2012, JX459908) to human and animal gastrointestinal mucins. We provide evidence that inhibitory effects on capsid binding are exerted in a competitive manner by alpha-fucosyl residues on Fucus vesiculosus fucoidan, but also on the galacto-fucan from Undaria pinnatifida and their oligo-fucose processing products. Insight into novel structural aspects of fucoidan and derived oligosaccharides from low-mass Undaria pinnatifida were revealed by GCMS and MALDI mass spectrometry. In targeting noroviral spread attenuation, this study provides first steps towards a prophylactic food additive that is produced from algal species.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hanisch, Franz-Georg UNSPECIFIED orcid.org/0000-0003-3619-7039 UNSPECIFIED Aydogan, Cem UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroten, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-575991
DOI:	10.3390/md19110591
Journal or Publication Title:	Mar. Drugs
Volume:	19
Number:	11
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1660-3397
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD GROUP ANTIGENS; GASTROENTERITIS Multiple languages Chemistry, Medicinal; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57599