Universität zu Köln

Rieckher, Matthias, Garinis, George A. and Schumacher, Bjorn (2021). Molecular pathology of rare progeroid diseases. Trends Mol. Med, 27 (9). S. 907 - 923. OXFORD: ELSEVIER SCI LTD. ISSN 1471-499X

Full text not available from this repository.

Abstract

Progeroid syndromes (PSs) are characterized by the premature onset of age related pathologies. The genetic mutations underlying PSs are functionally linked to genome maintenance and repair, supporting the causative role of DNA damage accumulation in aging. Recent advances from studies in animal models of PSs have provided new insight into the role of DNA repair mechanisms in human disease and the physiological adaptations to accumulating DNA damage during aging. The molecular pathology of PSs is reminiscent of the natural aging process, highlighting the relevance for a wide range of age-related diseases. Recent progress has led to the development of novel therapeutic strategies against age-related diseases that are relevant to rare diseases as well as the general aging population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rieckher, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Garinis, George A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjorn UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576318
DOI:	10.1016/j.molmed.2021.06.011
Journal or Publication Title:	Trends Mol. Med
Volume:	27
Number:	9
Page Range:	S. 907 - 923
Date:	2021
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1471-499X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEOTIDE EXCISION-REPAIR; DNA-DAMAGE RESPONSE; CAENORHABDITIS-ELEGANS; LIFE-SPAN; CANCER PREDISPOSITION; MOUSE MODEL; DYSKERATOSIS-CONGENITA; TELOMERE MAINTENANCE; CELLULAR SENESCENCE; MICE DEFICIENT Multiple languages Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57631