Universität zu Köln

Sahin, Derya, Hever, Felix, Bossert, Magdalena, Herwig, Kerstin, Aschenbrenner, Steffen, Weisbrod, Matthias and Sharma, Anuradha (2021). Early and middle latency auditory event-related potentials do not explain differences in neuropsychological performance between schizophrenia spectrum patients and matched healthy controls. Psychiatry Res., 304. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7123

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Abstract

Abnormalities of early and middle latency auditory event-related potentials (ERPs) are widespread in schizophrenia and have been suggested to be associated with cognitive deficits in schizophrenia patients. In this cross-sectional study with schizophrenia patients (n=30) and psychiatrically healthy counterparts (n=31) (matched for age, sex, education), we investigated whether auditory information processing (measured via amplitudes and gating of the auditory ERPs P50, N100 and P200) correlates with neuropsychological performance across cognitive domains. The groups differed significantly in amplitudes and gating of N100 and P200 potentials as well as in neuropsychological performance, but not in P50 amplitude and gating. Neither amplitudes nor gating of auditory ERPs correlated with neuropsychological performance. Neuropsychological intergroup differences could not be explained by abnormalities in auditory information processing. Although pronounced impairments exist on the levels of both auditory information processing and cognitive performance in schizophrenia, these abnormalities are not directly associated with each other.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sahin, Derya UNSPECIFIED UNSPECIFIED UNSPECIFIED Hever, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Bossert, Magdalena UNSPECIFIED UNSPECIFIED UNSPECIFIED Herwig, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Aschenbrenner, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Weisbrod, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, Anuradha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576796
DOI:	10.1016/j.psychres.2021.114162
Journal or Publication Title:	Psychiatry Res.
Volume:	304
Date:	2021
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-7123
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SENSORY GATING DEFICITS; TEST-RETEST RELIABILITY; P50 SUPPRESSION; 1ST-EPISODE SCHIZOPHRENIA; SCHIZOAFFECTIVE DISORDER; N100; ABNORMALITIES; METAANALYSIS; INHIBITION; ATTENTION Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57679