Universität zu Köln

Gouni-Berthold, Ioanna and Berthold, Heiner K. (2021). Vitamin D and Vascular Disease. Current Vascular Pharmacology, 19 (3). S. 250 - 269. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1875-6212

Full text not available from this repository.

Abstract

Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Vitamin D deficiency has been identified as a potential risk factor for a number of diseases unrelated to the classical skeletal pathophysiology, such as cancer and CVD, but the effects of vitamin D supplementation are less clear. Purpose of this narrative review is to discuss the evidence suggesting an association between vitamin D status and CVD as well as the results of supplementation studies. Vitamin D deficiency has been associated with CVD risk factors such as hypertension, dyslipidemia and diabetes mellitus as well as with cardiovascular events such as myocardial infarction, stroke and heart failure. While vitamin D deficiency might contribute to the development of CVD through its association with risk factors, direct effects of vitamin D on the cardiovascular system may also be involved. Vitamin D receptors are expressed in a variety of tissues, including cardiomyocytes, vascular smooth muscle cells and endothelial cells. Moreover, vitamin D has been shown to affect inflammation, cell proliferation and differentiation. While observational studies support an association between low plasma vitamin D levels and increased risk of CVD, Mendelian randomization studies do not support a causal association between the two. At present, high quality randomized trials do not find evidence of significant effects on CVD endpoints and do not support supplementation of vitamin D to decrease CVD events.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, Heiner K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-577340
DOI:	10.2174/1570161118666200317151955
Journal or Publication Title:	Current Vascular Pharmacology
Volume:	19
Number:	3
Page Range:	S. 250 - 269
Date:	2021
Publisher:	BENTHAM SCIENCE PUBL LTD
Place of Publication:	SHARJAH
ISSN:	1875-6212
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SERUM 25-HYDROXYVITAMIN D; 3RD NATIONAL-HEALTH; 1,25-DIHYDROXYVITAMIN D-3 RECEPTOR; DEPENDENT GAMMA-CARBOXYLATION; CARDIOVASCULAR RISK-FACTORS; PARATHYROID-HORMONE LEVELS; CONGESTIVE-HEART-FAILURE; D-BINDING PROTEIN; D SUPPLEMENTATION; D DEFICIENCY Multiple languages Pharmacology & Pharmacy; Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57734