Wegner, Joanna, Weidenthaler-Barth, Beate, Engelbert, Julia, Knothe, Max, Braun, Claudia, Helbig, Doris, Sacher, Christopher, Kreft, Andreas, Wagner, Eva M., Ziemer, Mirjana, Meyer, Ralf G. and von Stebut, Esther (2021). Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graft-versus-host disease. Exp. Dermatol., 30 (12). S. 1814 - 1820. HOBOKEN: WILEY. ISSN 1600-0625
Full text not available from this repository.Abstract
Graft-versus-host disease (GvHD) is a major complication following stem-cell or solid-organ transplantation. Accurate diagnosis of cutaneous GvHD is challenging, given that drug eruptions and viral rashes may present with similar clinical/histological manifestations. Specific markers are not available. We performed the histological examination of biopsy samples from acute GvHD (aGvHD; n = 54), Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN; n = 27), maculopapular drug eruption (MDE; n = 26) and healthy controls (n = 26). Samples of aGvHD showed a decrease in Langerhans cells (LC, p = 0.0001) and an increase in macrophages (M phi, p = 0.0001) compared to healthy skin. Compared to SJS/TEN, MDE and healthy skin, aGvHD biopsies contained greater numbers of CD4(+) and CD8(+) T cells. The majority of CD4(+) T-helper cells were localized in the upper dermis, whereas cytotoxic CD8(+) T cells were found in the epidermis. Increased numbers of CD56(+) natural killer (NK) cells in the upper dermis of aGvHD skin (p = 0.007) were not observed in controls or SJS/TEN and MDE. There were no differences in elafin staining between aGvHD and the latter two conditions. Acute GvHD appears to have a distinct inflammatory cell profile (T cells/NK cells) that may aid establishing in a more accurate diagnosis, especially when used to rule out differential diagnoses such as SJS/TEN or MDE.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-577974 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1111/exd.14416 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Exp. Dermatol. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Volume: | 30 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Number: | 12 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 1814 - 1820 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Date: | 2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | WILEY | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Place of Publication: | HOBOKEN | ||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1600-0625 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/57797 |
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