Universität zu Köln

Walter, Sebastian G., Scheidt, Sebastian, Nissler, Robert ORCID: 0000-0003-1282-2901, Gaisendrees, Christopher ORCID: 0000-0002-7232-3330, Zarghooni, Kourosh ORCID: 0000-0001-7069-6291 and Schildberg, Frank A. (2021). In-Depth Characterization of Stromal Cells within the Tumor Microenvironment Yields Novel Therapeutic Targets. Cancers, 13 (6). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary This up-to-date and in-depth review describes fibroblast-derived cells and their role within the tumor microenvironment for tumor progression. Moreover, targets for future antitumor therapies are summarized and potential aspects for future translational research are outlined. Furthermore, this review discusses the challenges and possible obstacles related to certain treatment targets. Cells within the tumor stroma are essential for tumor progression. In particular, cancer-associated fibroblasts (CAF) and CAF precursor cells (resident fibroblasts and mesenchymal stromal cells) are responsible for the formation of the extracellular matrix in tumor tissue. Consequently, CAFs directly and indirectly mediate inflammation, metastasis, immunomodulation, angiogenesis, and the development of tumor chemoresistance, which is orchestrated by complex intercellular cytokine-mediated crosstalk. CAFs represent a strategic target in antitumor therapy but their heterogeneity hinders effective treatment regimes. In-depth understanding of CAF subpopulations and knowledge of specific functions in tumor progression will ultimately result in more specific and effective cancer treatments. This review provides a detailed description of CAFs and CAF precursor cells and summarizes possible treatment strategies as well as molecular targets of these cells in antitumor therapies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Walter, Sebastian G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheidt, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Nissler, Robert UNSPECIFIED orcid.org/0000-0003-1282-2901 UNSPECIFIED Gaisendrees, Christopher UNSPECIFIED orcid.org/0000-0002-7232-3330 UNSPECIFIED Zarghooni, Kourosh UNSPECIFIED orcid.org/0000-0001-7069-6291 UNSPECIFIED Schildberg, Frank A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578038
DOI:	10.3390/cancers13061466
Journal or Publication Title:	Cancers
Volume:	13
Number:	6
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57803