Universität zu Köln

Hu, Linli, Xiong, Yujing, Wang, Mengying, Shi, Hao and Sun, Yingpu (2021). Effect of progesterone on hCG day-to-basal progesterone ratio on live birth rate in long agonist fresh IVF/ICSI cycles: a 5-year, single-center study of more than 10,000 cycles. Gynecol. Endocrinol., 37 (8). S. 706 - 711. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1473-0766

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Abstract

Objective: To investigate whether the ratio of the serum progesterone level on the day of human chorionic gonadotrophin (hCG) administration to the basal serum progesterone level (P-hCG/P-basal) is a predictor of pregnancy outcome during in vitro fertilization (IVF). Methods: A total of 12,708 cycles were performed in 9747 patients between 19 and 36 years of age who were undergoing controlled ovarian stimulation from October 2011 to July 2016 for their first or second attempts at IVF followed by fresh embryo transfer (ET). hCG was administered 36 h before oocyte retrieval to trigger final oocyte maturation. The serum progesterone level was measured on menstrual cycle days 2-4 (basal progesterone, P-basal) and on the day of hCG administration (P-hCG). P-hCG/P-basal was calculated. Live birth rates were compared among various ordinal P-hCG/P-basal intervals (< 0.5, 0.5-1.0, 1.0-1.5, 1.5-2.0, 2.0-2.5, > 2.5). Results: The average age of the patients recruited was 29.9 years. The average basal progesterone level was 0.8 ng/ml, while the average progesterone level on the day of hCG administration was 0.9 ng/ml. The live birth rates (according to the abovementioned ordinal P-hCG/P-basal intervals) were 47.3, 49.9, 47.8, 46.3, 45.5 and 44.0%, respectively. The live birth rates were significantly higher for patients with P-hCG/P-basal between 0.5-1.0 (OR = 1.14, 95% CI, 1.02-1.27, p = .02). Conclusions: P-hCG/P-basal between 0.5-1.0 predicts a higher live birth rate in IVF. Both P-hCG/P-basal and P on hCG day is less predictive value for predicting live birth rate.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hu, Linli UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiong, Yujing UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Mengying UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Hao UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Yingpu UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578268
DOI:	10.1080/09513590.2020.1832067
Journal or Publication Title:	Gynecol. Endocrinol.
Volume:	37
Number:	8
Page Range:	S. 706 - 711
Date:	2021
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1473-0766
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Endocrinology & Metabolism; Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57826