Universität zu Köln

Balaji, Harini, Demers, Imke ORCID: 0000-0001-9531-8414, Wuerdemann, Nora ORCID: 0000-0002-1092-689X, Schrijnder, Julia, Kremer, Bernd, Klussmann, Jens Peter, Huebbers, Christian Ulrich and Speel, Ernst-Jan Maria (2021). Causes and Consequences of HPV Integration in Head and Neck Squamous Cell Carcinomas: State of the Art. Cancers, 13 (16). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary In human papillomavirus (HPV) associated head and neck squamous cell carcinomas (HNSCC) s, the HPV genome is commonly found integrated in the human genome. The event of viral-human genome integration may act as a driver of carcinogenesis. Hence, it is vital to assess the viral integration status of a tumor. In this review, current and emerging techniques for integration detection are thoroughly discussed with their advantages and disadvantages. Additionally, the review also discusses the causes of HPV integration into the cellular genome, as well as its ramifications, impacting possible clinical implications. A constantly increasing incidence in high-risk Human Papillomaviruses (HPV)s driven head and neck squamous cell carcinomas (HNSCC)s, especially of oropharyngeal origin, is being observed. During persistent infections, viral DNA integration into the host genome may occur. Studies are examining if the physical status of the virus (episomal vs. integration) affects carcinogenesis and eventually has further-reaching consequences on disease progression and outcome. Here, we review the literature of the most recent five years focusing on the impact of HPV integration in HNSCCs, covering aspects of detection techniques used (from PCR up to NGS approaches), integration loci identified, and associations with genomic and clinical data. The consequences of HPV integration in the human genome, including the methylation status and deregulation of genes involved in cell signaling pathways, immune evasion, and response to therapy, are also summarized.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Balaji, Harini UNSPECIFIED UNSPECIFIED UNSPECIFIED Demers, Imke UNSPECIFIED orcid.org/0000-0001-9531-8414 UNSPECIFIED Wuerdemann, Nora UNSPECIFIED orcid.org/0000-0002-1092-689X UNSPECIFIED Schrijnder, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Kremer, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, Jens Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebbers, Christian Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Speel, Ernst-Jan Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578564
DOI:	10.3390/cancers13164089
Journal or Publication Title:	Cancers
Volume:	13
Number:	16
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-PAPILLOMAVIRUS; HIGH-RISK; DNA INTEGRATION; GENE-EXPRESSION; POSITIVE HEAD; VIRAL LOAD; OPEN-LABEL; CANCER; SITES; RECURRENT Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57856