Wu, Fengying, Fan, Jue, He, Yayi, Xiong, Anwen, Yu, Jia, Li, Yixin, Zhang, Yan, Zhao, Wencheng, Zhou, Fei, Li, Wei, Zhang, Jie, Zhang, Xiaosheng, Qiao, Meng, Gao, Guanghui, Chen, Shanhao, Chen, Xiaoxia, Li, Xuefei, Hou, Likun, Wu, Chunyan, Su, Chunxia, Ren, Shengxiang, Odenthal, Margarete, Buettner, Reinhard, Fang, Nan and Zhou, Caicun (2021). Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nat. Commun., 12 (1). BERLIN: NATURE RESEARCH. ISSN 2041-1723

Full text not available from this repository.

Abstract

Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor microenvironment together determine disease progression, as well as response to or escape from treatment. To map the cell type-specific transcriptome landscape of cancer cells and their tumor microenvironment in advanced non-small cell lung cancer (NSCLC), we analyze 42 tissue biopsy samples from stage III/IV NSCLC patients by single cell RNA sequencing and present the large scale, single cell resolution profiles of advanced NSCLCs. In addition to cell types described in previous single cell studies of early stage lung cancer, we are able to identify rare cell types in tumors such as follicular dendritic cells and T helper 17 cells. Tumors from different patients display large heterogeneity in cellular composition, chromosomal structure, developmental trajectory, intercellular signaling network and phenotype dominance. Our study also reveals a correlation of tumor heterogeneity with tumor associated neutrophils, which might help to shed light on their function in NSCLC. Comprehensive profiles of tumour and microenvironment are critical to understand heterogeneity in non-small cell lung cancer (NSCLC). Here, the authors profile 42 late-stage NSCLC patients with single-cell RNA-seq, revealing immune landscapes that are associated with cancer subtype or heterogeneity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wu, FengyingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fan, JueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
He, YayiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xiong, AnwenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yu, JiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, YixinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, YanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, WenchengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhou, FeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, WeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, XiaoshengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qiao, MengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gao, GuanghuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, ShanhaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, XiaoxiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, XuefeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hou, LikunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wu, ChunyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Su, ChunxiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ren, ShengxiangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Odenthal, MargareteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fang, NanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhou, CaicunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-578640
DOI: 10.1038/s41467-021-22801-0
Journal or Publication Title: Nat. Commun.
Volume: 12
Number: 1
Date: 2021
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EXPRESSION; DIFFERENTIATION; BIOLOGY; FATEMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57864

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item