Universität zu Köln

Imach, Sebastian, Wafaisade, Arasch, Lefering, Rolf, Boehmer, Andreas, Schieren, Mark, Suarez, Victor and Froehlich, Matthias (2021). The impact of prehospital tranexamic acid on mortality and transfusion requirements: match-pair analysis from the nationwide German TraumaRegister DGU (R). Crit. Care, 25 (1). LONDON: BMC. ISSN 1466-609X

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Abstract

BackgroundOutcome data about the use of tranexamic acid (TXA) in civilian patients in mature trauma systems are scarce. The aim of this study was to determine how severely injured patients are affected by the widespread prehospital use of TXA in Germany.MethodsThe international TraumaRegister DGU (R) was retrospectively analyzed for severely injured patients with risk of bleeding (2015 until 2019) treated with at least one dose of TXA in the prehospital phase (TXA group). These were matched with patients who had not received prehospital TXA (control group), applying propensity score-based matching. Adult patients (>= 16) admitted to a trauma center in Germany with an Injury Severity Score (ISS)>= 9 points were included.ResultsThe matching yielded two comparable cohorts (n=2275 in each group), and the mean ISS was 32.414.7 in TXA group vs. 32.0 +/- 14.5 in control group (p=0.378). Around a third in both groups received one dose of TXA after hospital admission. TXA patients were significantly more transfused (p=0.022), but needed significantly less packed red blood cells (p <= 0.001) and fresh frozen plasma (p=0.023), when transfused. Massive transfusion rate was significantly lower in the TXA group (5.5% versus 7.2%, p=0.015). Mortality was similar except for early mortality after 6 h (p=0.004) and 12 h (p=0.045). Among non-survivors hemorrhage as leading cause of death was less in the TXA group (3.0% vs. 4.3%, p=0.021). Thromboembolic events were not significantly different between both groups (TXA 6.1%, control 4.9%, p=0.080).Conclusion This is the largest civilian study in which the effect of prehospital TXA use in a mature trauma system has been examined. TXA use in severely injured patients was associated with a significantly lower risk of massive transfusion and lower mortality in the early in-hospital treatment period. Due to repetitive administration, a dose-dependent effect of TXA must be discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Imach, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wafaisade, Arasch UNSPECIFIED UNSPECIFIED UNSPECIFIED Lefering, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehmer, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schieren, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Suarez, Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED Froehlich, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-579115
DOI:	10.1186/s13054-021-03701-7
Journal or Publication Title:	Crit. Care
Volume:	25
Number:	1
Date:	2021
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1466-609X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLEEDING TRAUMA PATIENTS; FIBRINOLYSIS SHUTDOWN; PRACTICE MANAGEMENT; HEMORRHAGE; RESUSCITATION; INJURY; CARE; REGISTRY; HYPERFIBRINOLYSIS; ASSOCIATION Multiple languages Critical Care Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57911