Matthaei, M., Hos, D., Bock, F., Le, V. N. H., Hou, Y., Schaub, F., Siebelmann, S., Zhang, W., Roters, S., Bachmann, B. O. and Cursiefen, C. (2021). Preconditioning of vascularized high-risk eyes using fine-needle diathermy and cross-linking. Ophthalmologe, 118 (6). S. 553 - 561. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423
Full text not available from this repository.Abstract
Background The risk of allograft rejection following high-risk keratoplasty increases with the area of corneal neovascularization. Pharmaceutical and physical regression of corneal neovascularization before keratoplasty may offer the potential to reduce the risk of graft rejection after high-risk keratoplasty. Objective This article provides a review of the literature on the preconditioning of vascularized high-risk eyes using fine-needle diathermy and corneal cross-linking (preoperative preconditioning by lymphangioregression). Methods A literature search was carried out in PubMed and a summary of own data is presented. Results Animal experimental studies showed that both fine-needle diathermy and corneal cross-linking lead to a regression of corneal neovascularization and prolong graft survival after high-risk keratoplasty. Furthermore, studies from our institute provide first evidence that both procedures also lead to a reduction of corneal neovascularization in the clinical practice and thus potentially reduce the risk of allograft rejection after subsequent high-risk keratoplasty. Discussion Fine-needle diathermy and corneal cross-linking provide effective therapeutic approaches for angioregressive treatment and seem to prolong graft survival following high-risk keratoplasty. Larger prospective and controlled clinical trials are needed to further investigate these promising therapeutic approaches.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-579927 | ||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1007/s00347-021-01415-3 | ||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Ophthalmologe | ||||||||||||||||||||||||||||||||||||||||||||||||
Volume: | 118 | ||||||||||||||||||||||||||||||||||||||||||||||||
Number: | 6 | ||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 553 - 561 | ||||||||||||||||||||||||||||||||||||||||||||||||
Date: | 2021 | ||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | SPRINGER HEIDELBERG | ||||||||||||||||||||||||||||||||||||||||||||||||
Place of Publication: | HEIDELBERG | ||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1433-0423 | ||||||||||||||||||||||||||||||||||||||||||||||||
Language: | German | ||||||||||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/57992 |
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