Universität zu Köln

Pokorny, Lena ORCID: 0000-0001-5638-0813, Besting, Lisa, Roebruck, Friederike, Jarczok, Tomasz Antoni and Bender, Stephan (2022). Fearful facial expressions reduce inhibition levels in the dorsolateral prefrontal cortex in subjects with specific phobia. Depress. Anxiety, 39 (1). S. 26 - 37. HOBOKEN: WILEY. ISSN 1520-6394

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Abstract

Background Specific phobias have the highest prevalence among anxiety disorders. Cognitive control involving the dorsolateral prefrontal cortex (DLPFC) is crucial for coping abilities in anxiety disorders. However, there is little research on the DLPFC in specific phobia. Methods Using transcranial magnetic stimulation (TMS), we investigated the TMS-evoked potential component N100 in the DLPFC at rest and while watching emotional expressions. The TMS-evoked N100 provides a parameter for gamma-aminobutyric acid (GABA)-B-mediated cortical inhibition. Twenty-two drug-free subjects with specific phobia (21 females and 1 male) were compared with 26 control subjects (23 females and 3 males) regarding N100 in the DLPFC at rest and during an emotional 1-back task with fearful, angry, and neutral facial expressions. Results At rest, we found reduced N100 amplitudes in the specific phobia compared with the control group. Furthermore, the specific phobia group showed a further reduction in N100 amplitude when memorizing fearful compared with neutral facial expressions. Conclusion There appears to be a decrease in GABA-B-mediated inhibition in the DLPFC in subjects with a specific phobia at rest. This decrease was more pronounced under emotional activation by exposure to fearful facial expressions, pointing towards additional state effects of emotional processing on inhibitory function in the DLPFC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pokorny, Lena UNSPECIFIED orcid.org/0000-0001-5638-0813 UNSPECIFIED Besting, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Roebruck, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Jarczok, Tomasz Antoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-580409
DOI:	10.1002/da.23217
Journal or Publication Title:	Depress. Anxiety
Volume:	39
Number:	1
Page Range:	S. 26 - 37
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1520-6394
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE PERFORMANCE; CORTICAL INHIBITION; GABA(B) RECEPTORS; BRAIN ACTIVATION; TRAIT ANXIETY; TMS; AMYGDALA; NEUROTRANSMISSION; CONNECTIVITY; POTENTIALS Multiple languages Psychology, Clinical; Psychiatry; Psychology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58040