Predictors of COVID-19 in an outpatient fever clinic - Kölner UniversitätsPublikationsServer

Truebner, Frank, Steigert, Lisa, Echterdiek, Fabian ORCID: 0000-0001-7239-4959, Jung, Norma, Schmidt-Hellerau, Kirsten, Zoller, Wolfram G., Frick, Julia-Stefanie, Feng, You-Shan and Paul, Gregor ORCID: 0000-0002-1075-4362 (2021). Predictors of COVID-19 in an outpatient fever clinic. PLoS One, 16 (7). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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DOI:10.1371/journal.pone.0254990

Abstract

Background The objective of this study was to identify clinical risk factors for COVID-19 in a German outpatient fever clinic that allow distinction of SARS-CoV-2 infected patients from other patients with flu-like symptoms. Methods This is a retrospective, single-centre cohort study. Patients were included visiting the fever clinic from 4(th) of April 2020 to 15(th) of May 2020. Symptoms, comorbidities, and socio-demographic factors were recorded in a standardized fashion. Multivariate logistic regression was used to identify risk factors of COVID-19, on the bases of those a model discrimination was assessed using area under the receiver operation curves (AUROC). Results The final analysis included 930 patients, of which 74 (8%) had COVID-19. Anosmia (OR 10.71; CI 6.07-18.9) and ageusia (OR 9.3; CI 5.36-16.12) were strongly associated with COVID-19. High-risk exposure (OR 12.20; CI 6.80-21.90), especially in the same household (OR 4.14; CI 1.28-13.33), was also correlated; the more household members, especially with flu-like symptoms, the higher the risk of COVID-19. Working in an essential workplace was also associated with COVID-19 (OR 2.35; CI 1.40-3.96), whereas smoking was inversely correlated (OR 0.19; CI 0.08-0.44). A model that considered risk factors like anosmia, ageusia, concomitant of symptomatic household members and smoking well discriminated COVID-19 patients from other patients with flu-like symptoms (AUROC 0.84). Conclusions We report a set of four readily available clinical parameters that allow the identification of high-risk individuals of COVID-19. Our study will not replace molecular testing but will help guide containment efforts while waiting for test results.

Item Type:

Journal Article

Creators:

Creators	Email	ORCID	ORCID Put Code
Truebner, Frank	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Steigert, Lisa	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Echterdiek, Fabian	UNSPECIFIED	orcid.org/0000-0001-7239-4959	UNSPECIFIED
Jung, Norma	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Schmidt-Hellerau, Kirsten	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Zoller, Wolfram G.	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Frick, Julia-Stefanie	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Feng, You-Shan	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Paul, Gregor	UNSPECIFIED	orcid.org/0000-0002-1075-4362	UNSPECIFIED